TY - JOUR
T1 - Genetic variance and heritability of serum cholesterol and triglycerides among Chinese twin neonates
AU - Chen, C. J.
AU - Yu, M. W.
AU - Wang, C. J.
AU - Tong, S. L.
AU - Tien, M.
AU - Lee, T. Y.
AU - Lue, H. C.
AU - Huang, F. Y.
AU - Lan, C. C.
AU - Yang, K. H.
AU - Wang, H. C.
AU - Shih, H. Y.
AU - Liu, C. Y.
AU - Chen, J. S.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - In order to examine the genetic variance and heritability of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides, a total of 349 pairs of same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 271 monozygotic (MZ) and 78 dizygotic (DZ) twin pairs were identified. There was a significant genetic variance for total cholesterol, HDL-C, LDL-C, and triglycerides both unadjusted and adjusted for sex, gestational age and placentation. The unadjusted heritability of total cholesterol, HDL-C, LDL-C, and triglycerides was 0.59, 0.30, 0.25 and 0.75, respectively; while the corresponding adjusted heritability was 0.74, 0.38, 0.31, and 0.49, respectively. Intrapair variance of serum lipids was not significantly different between monochorionic and dichorionic MZ twins.
AB - In order to examine the genetic variance and heritability of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides, a total of 349 pairs of same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 271 monozygotic (MZ) and 78 dizygotic (DZ) twin pairs were identified. There was a significant genetic variance for total cholesterol, HDL-C, LDL-C, and triglycerides both unadjusted and adjusted for sex, gestational age and placentation. The unadjusted heritability of total cholesterol, HDL-C, LDL-C, and triglycerides was 0.59, 0.30, 0.25 and 0.75, respectively; while the corresponding adjusted heritability was 0.74, 0.38, 0.31, and 0.49, respectively. Intrapair variance of serum lipids was not significantly different between monochorionic and dichorionic MZ twins.
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U2 - 10.1017/S000156600000564X
DO - 10.1017/S000156600000564X
M3 - Article
C2 - 2392889
AN - SCOPUS:0025146752
SN - 0001-5660
VL - 39
SP - 123
EP - 131
JO - Acta Geneticae Medicae et Gemellologiae
JF - Acta Geneticae Medicae et Gemellologiae
IS - 1
ER -