Genetic variance and heritability of serum cholesterol and triglycerides among Chinese twin neonates

C. J. Chen, M. W. Yu, Chi-Jen Wang, S. L. Tong, M. Tien, T. Y. Lee, H. C. Lue, F. Y. Huang, C. C. Lan, K. H. Yang, H. C. Wang, H. Y. Shih, C. Y. Liu, J. S. Chen

研究成果: Article

2 引文 (Scopus)

摘要

In order to examine the genetic variance and heritability of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides, a total of 349 pairs of same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 271 monozygotic (MZ) and 78 dizygotic (DZ) twin pairs were identified. There was a significant genetic variance for total cholesterol, HDL-C, LDL-C, and triglycerides both unadjusted and adjusted for sex, gestational age and placentation. The unadjusted heritability of total cholesterol, HDL-C, LDL-C, and triglycerides was 0.59, 0.30, 0.25 and 0.75, respectively; while the corresponding adjusted heritability was 0.74, 0.38, 0.31, and 0.49, respectively. Intrapair variance of serum lipids was not significantly different between monochorionic and dichorionic MZ twins.

原文English
頁(從 - 到)123-131
頁數9
期刊Acta Geneticae Medicae et Gemellologiae
39
發行號1
DOIs
出版狀態Published - 1990 一月 1

指紋

LDL Cholesterol
HDL Cholesterol
Triglycerides
Cholesterol
Newborn Infant
Serum
Dizygotic Twins
Placentation
Monozygotic Twins
Teaching Hospitals
General Hospitals
Gestational Age
Erythrocytes
Lipids
Antigens
low density lipoprotein triglyceride

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)

引用此文

Chen, C. J. ; Yu, M. W. ; Wang, Chi-Jen ; Tong, S. L. ; Tien, M. ; Lee, T. Y. ; Lue, H. C. ; Huang, F. Y. ; Lan, C. C. ; Yang, K. H. ; Wang, H. C. ; Shih, H. Y. ; Liu, C. Y. ; Chen, J. S. / Genetic variance and heritability of serum cholesterol and triglycerides among Chinese twin neonates. 於: Acta Geneticae Medicae et Gemellologiae. 1990 ; 卷 39, 編號 1. 頁 123-131.
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abstract = "In order to examine the genetic variance and heritability of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides, a total of 349 pairs of same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 271 monozygotic (MZ) and 78 dizygotic (DZ) twin pairs were identified. There was a significant genetic variance for total cholesterol, HDL-C, LDL-C, and triglycerides both unadjusted and adjusted for sex, gestational age and placentation. The unadjusted heritability of total cholesterol, HDL-C, LDL-C, and triglycerides was 0.59, 0.30, 0.25 and 0.75, respectively; while the corresponding adjusted heritability was 0.74, 0.38, 0.31, and 0.49, respectively. Intrapair variance of serum lipids was not significantly different between monochorionic and dichorionic MZ twins.",
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Chen, CJ, Yu, MW, Wang, C-J, Tong, SL, Tien, M, Lee, TY, Lue, HC, Huang, FY, Lan, CC, Yang, KH, Wang, HC, Shih, HY, Liu, CY & Chen, JS 1990, 'Genetic variance and heritability of serum cholesterol and triglycerides among Chinese twin neonates', Acta Geneticae Medicae et Gemellologiae, 卷 39, 編號 1, 頁 123-131. https://doi.org/10.1017/S000156600000564X

Genetic variance and heritability of serum cholesterol and triglycerides among Chinese twin neonates. / Chen, C. J.; Yu, M. W.; Wang, Chi-Jen; Tong, S. L.; Tien, M.; Lee, T. Y.; Lue, H. C.; Huang, F. Y.; Lan, C. C.; Yang, K. H.; Wang, H. C.; Shih, H. Y.; Liu, C. Y.; Chen, J. S.

於: Acta Geneticae Medicae et Gemellologiae, 卷 39, 編號 1, 01.01.1990, p. 123-131.

研究成果: Article

TY - JOUR

T1 - Genetic variance and heritability of serum cholesterol and triglycerides among Chinese twin neonates

AU - Chen, C. J.

AU - Yu, M. W.

AU - Wang, Chi-Jen

AU - Tong, S. L.

AU - Tien, M.

AU - Lee, T. Y.

AU - Lue, H. C.

AU - Huang, F. Y.

AU - Lan, C. C.

AU - Yang, K. H.

AU - Wang, H. C.

AU - Shih, H. Y.

AU - Liu, C. Y.

AU - Chen, J. S.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - In order to examine the genetic variance and heritability of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides, a total of 349 pairs of same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 271 monozygotic (MZ) and 78 dizygotic (DZ) twin pairs were identified. There was a significant genetic variance for total cholesterol, HDL-C, LDL-C, and triglycerides both unadjusted and adjusted for sex, gestational age and placentation. The unadjusted heritability of total cholesterol, HDL-C, LDL-C, and triglycerides was 0.59, 0.30, 0.25 and 0.75, respectively; while the corresponding adjusted heritability was 0.74, 0.38, 0.31, and 0.49, respectively. Intrapair variance of serum lipids was not significantly different between monochorionic and dichorionic MZ twins.

AB - In order to examine the genetic variance and heritability of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides, a total of 349 pairs of same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 271 monozygotic (MZ) and 78 dizygotic (DZ) twin pairs were identified. There was a significant genetic variance for total cholesterol, HDL-C, LDL-C, and triglycerides both unadjusted and adjusted for sex, gestational age and placentation. The unadjusted heritability of total cholesterol, HDL-C, LDL-C, and triglycerides was 0.59, 0.30, 0.25 and 0.75, respectively; while the corresponding adjusted heritability was 0.74, 0.38, 0.31, and 0.49, respectively. Intrapair variance of serum lipids was not significantly different between monochorionic and dichorionic MZ twins.

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