Gestational risk factors and childhood cancers: A cohort study in Taiwan

Julia E. Heck, Pei Chen Lee, Chia Kai Wu, Hsin Yun Tsai, Beate Ritz, Onyebuchi A. Arah, Chung Yi Li

研究成果: Article

摘要

Gestational risk factors such as birth weight, gestational age and parity have been repeatedly found to be related to pediatric cancers, but few reports have emerged from Asian countries. Here we report on demographic and gestational factors in a Taiwanese cohort. Our study included all children born in Taiwan 2004–2014 for whom there was a birth record (n = 2,079,037), of which 1900 children had been diagnosed with cancer prior to age 12. We conducted multivariable hazard regression to examine associations between demographic and gestational factors with cancer. Greater parity (family with 2+ older children) was related to acute myeloid leukemia [Hazard ratio (HR) = 2.15, 95% confidence interval (CI): 1.31, 3.55), central nervous system tumors (HR = 1.67, CI: 1.13, 2.48) and neuroblastoma (HR = 1.67, CI: 1.07, 2.63). Hepatoblastoma cases had a higher risk of low birth weight (<2,500 g; HR = 3.01, CI: 1.85, 4.91), very preterm birth (<33 weeks gestation; HR = 13.71, CI: 7.45, 25.23), plural pregnancies (HR = 2.37, CI: 1.10, 5.14) and both small (HR = 2.13, CI: 1.23, 3.67) and large (HR = 1.83, CI: 1.01, 3.32) for gestational age. Germ cell tumors were more common among children born in rural areas (HR = 1.63, CI: 1.02, 2.60). Despite that Taiwan has lower rates of both high and low birthweight compared to other developed nations, we observed several similar associations to those reported in Western Countries. Further research should examine unique exposures in Taiwan that may be contributing to higher incidence of certain cancer types.

原文English
期刊International Journal of Cancer
DOIs
出版狀態Accepted/In press - 2020 一月 1

    指紋

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

引用此

Heck, J. E., Lee, P. C., Wu, C. K., Tsai, H. Y., Ritz, B., Arah, O. A., & Li, C. Y. (認可的出版社/出版中). Gestational risk factors and childhood cancers: A cohort study in Taiwan. International Journal of Cancer. https://doi.org/10.1002/ijc.32905