Gold-catalyzed bicyclic annulations of 4-methoxy-1,2-dienyl-5-ynes with isoxazoles to form indolizine derivatives: Via an Au-π-allene intermediate

Antony Sekar Kulandai Raj, Kuo Chen Tan, Liang Yu Chen, Mu Jeng Cheng, Rai Shung Liu

研究成果: Article

10 引文 斯高帕斯(Scopus)

摘要

Gold-catalyzed bicyclic annulations of 4-methoxy-1,2-dienyl-5-ynes with isoxazoles afford indolizine derivatives with a structural rearrangement. The mechanism of these new annulations does not involve α-imino gold carbenes generated from gold π-alkyne intermediates. We postulate alkyne attack on gold π-allenes, yielding vinyl gold carbenes. These newly generated carbenes react with isoxazole derivatives to yield Z-3-imino-2-en-1-als, further enabling sequential cyclizations to deliver indolizine derivatives in two distinct classes.

原文English
頁(從 - 到)6437-6442
頁數6
期刊Chemical Science
10
發行號26
DOIs
出版狀態Published - 2019

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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