Gold nanomaterials conjugated with indocyanine green for dual-modality photodynamic and photothermal therapy

Wen Shuo Kuo, Yi Ting Chang, Keng Chi Cho, Kuo Chih Chiu, Chi Hsiang Lien, Chen Sheng Yeh, Shean Jen Chen

研究成果: Article同行評審

222 引文 斯高帕斯(Scopus)

摘要

Light-exposure-mediated higher temperatures that markedly accelerate the degradation of indocyanine green (ICG) in aqueous solutions by thermal decomposition have been a serious medical problem. In this work, we present the example of using gold nanorods (Au NRs) and gold nanoparticles (Au NPs) simultaneously serving as photodynamic and photothermal agents to destroy malignant cells. Au NRs and Au NPs were successfully conjugated with hydrophilic photosensitizer, indocyanine green (ICG), to achieve photodynamic therapy (PDT) and photothermal therapy (PTT). We also demonstrated that Au NRs and Au NPs conjugated with ICG displayed high chemical stability and acted as a promising diagnostic probe. Moreover, the photochemical destruction ability would have a gradually increase depending on different sizes of Au NPs. Due to its stability even via higher temperatures mediated by laser irradiation, the combination of PTT and PDT proved to be efficiently killing cancer cells as compared to PTT or PDT treatment alone and enhanced the effectiveness of photodestruction and was demonstrated to enhance its photostability. As a result, the preparation of Au-based nanomaterials conjugated with ICG as well as their use in biomedical applications is valuable developments in multifunctional nanomaterials.

原文English
頁(從 - 到)3270-3278
頁數9
期刊Biomaterials
33
發行號11
DOIs
出版狀態Published - 2012 四月

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 陶瓷和複合材料
  • 生物物理學
  • 生物材料
  • 材料力學

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