Grafting of 2-hydroxypropyl-β-cyclodextrin on gum Arabic-modified iron oxide nanoparticles as a magnetic carrier for targeted delivery of hydrophobic anticancer drug

Shashwat S. Banerjee, Dong Hwang Chen

研究成果: Article同行評審

34 引文 斯高帕斯(Scopus)

摘要

A new magnetic nanocarrier for the targeted delivery of hydrophobic drugs was developed by modifying magnetic nanoparticles with gum arabic and grafting with 2-hydroxypropyl-cyclodextrins (HCD) using hexamethylene diisocyanate (HMDI) as a linker. The size, hydrodynamic diameter, and grafting of HCD were characterized. The resultant magnetic nanocarrier exhibited an excellent capability to load all-trans-retinoic acid (ATRA), an anticancer agent. The better biocompatibility and the combined properties of specific targeting and complexation ability with hydrophobic drugs make the nanosystem an exciting prospect for targeted delivery of hydrophobic drugs.

原文English
頁(從 - 到)111-118
頁數8
期刊International Journal of Applied Ceramic Technology
7
發行號1
DOIs
出版狀態Published - 2010 1月

All Science Journal Classification (ASJC) codes

  • 陶瓷和複合材料
  • 凝聚態物理學
  • 行銷
  • 材料化學

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