摘要
Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm-2), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 185-194 |
| 頁數 | 10 |
| 期刊 | Biomaterials |
| 卷 | 120 |
| DOIs | |
| 出版狀態 | Published - 2017 三月 1 |
指紋
All Science Journal Classification (ASJC) codes
- Bioengineering
- Ceramics and Composites
- Biophysics
- Biomaterials
- Mechanics of Materials
引用此文
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Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging. / Kuo, Wen Shuo; Chen, Hua Han; Chen, Shih Yao; Chang, Chia Yuan; Chen, Pei Chi; Hou, Yung I.; Shao, Yu Ting; Kao, Hui Fang; Lilian Hsu, Chih Li; Chen, Yi Chun; Chen, Shean Jen; Wu, Shang Rung; Wang, Jiu Yao.
於: Biomaterials, 卷 120, 01.03.2017, p. 185-194.研究成果: Article
TY - JOUR
T1 - Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging
AU - Kuo, Wen Shuo
AU - Chen, Hua Han
AU - Chen, Shih Yao
AU - Chang, Chia Yuan
AU - Chen, Pei Chi
AU - Hou, Yung I.
AU - Shao, Yu Ting
AU - Kao, Hui Fang
AU - Lilian Hsu, Chih Li
AU - Chen, Yi Chun
AU - Chen, Shean Jen
AU - Wu, Shang Rung
AU - Wang, Jiu Yao
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm-2), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria.
AB - Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm-2), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria.
UR - http://www.scopus.com/inward/record.url?scp=85008406244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85008406244&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2016.12.022
DO - 10.1016/j.biomaterials.2016.12.022
M3 - Article
C2 - 28063357
AN - SCOPUS:85008406244
VL - 120
SP - 185
EP - 194
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
ER -