Greater availability of dopamine transporters in patients with major depression - A dual-isotope SPECT study

Yen Kuang Yang, Tzung Lieh Yeh, Wei Jen Yao, I. Hui Lee, Po See Chen, Nan Tsing Chiu, Ru Band Lu

研究成果: Article同行評審

53 引文 斯高帕斯(Scopus)

摘要

In order to explore the neuropathology of the pre- and post-synaptic dopamine neurons of patients with major depression, we examined striatal D2/D3 receptor uptake and dopamine transporter (DAT) availability simultaneously in drug-free depressed patients using a dual-isotope single photon emission computed tomography (SPECT) imaging technique. Ten unmedicated patients with unmediated depression and ten healthy controls were recruited. The striatal dopamine D2/D3 receptor availability was measured using SPECT and [123I] IBZM, while DAT was measured using SPECT and [99mTc] TRODAT-1. The symptom changes of the drug-free patients were reassessed after a 4-week antidepressant treatment. DAT binding in the patient group were significantly higher than in control group. That was not the case, however, for striatal D2/D3 receptor availability. Pre-treatment striatal DAT availability correlated only marginally with changes in the Hamilton Depression Rating Scale after 4 weeks of treatment. Central dopamine functions may be altered in patients with major depression, particularly in the pre-synaptic sites.

原文English
頁(從 - 到)230-235
頁數6
期刊Psychiatry Research - Neuroimaging
162
發行號3
DOIs
出版狀態Published - 2008 四月 15

All Science Journal Classification (ASJC) codes

  • 神經科學(雜項)
  • 放射學、核子醫學和影像學
  • 精神病學和心理健康

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