Grouping a few sets of normally distributed voxels of SPECT volumes in discrimination between alzheimer dementia and controls

研究成果: Conference contribution

摘要

It is widely accepted and can be easily verified that any specific voxel in a class of brain single photon emission computed tomography (SPECT) volumes is of a univariate normal distribution. In this research, we conjecture that all the voxels in a class of SPECT volumes are also approximately of a multivariate normal (MVN) distribution from which in terms of the Bayes errors of statistics, an optimal classifier can be designed using quadratic discriminant functions (QDFs). However, the number of training volumes needed for deriving the covariance matrix of an MVN distribution increases quadratically with respect to the number of voxels such that practically the MVN distributions cannot be modeled. To overcome this, we selected a reduced number of voxels and put them into groups based on the P values of two-sided t tests or a greedy algorithm of discrimination between two classes of volumes. We also tried the same approach on the 3DHaar wavelet coefficients which were obtained from the discrete wavelet transform of the voxels. Experiments showed that the accuracies of QDFs, linear discriminant functions (LDFs), and support vector machines (SVMs) were not significantly different in discrimination between Alzheimer's and normal controls verifying that the proposed MVNs effectively model the discrimination information. Moreover, the proposed QDF classifier obtained satisfactory performance.

原文English
主出版物標題2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
頁面6126-6129
頁數4
DOIs
出版狀態Published - 2010 十二月 1
事件2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 - Buenos Aires, Argentina
持續時間: 2010 八月 312010 九月 4

出版系列

名字2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10

Other

Other2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
國家Argentina
城市Buenos Aires
期間10-08-3110-09-04

指紋

Single photon emission computed tomography
Normal Distribution
Normal distribution
Single-Photon Emission-Computed Tomography
Alzheimer Disease
Classifiers
Wavelet Analysis
Discrete wavelet transforms
Covariance matrix
Support vector machines
Brain
Statistics
Research
Experiments

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Health Informatics

引用此文

Yin, T. K., Chiu, N-T., & Pai, M-C. (2010). Grouping a few sets of normally distributed voxels of SPECT volumes in discrimination between alzheimer dementia and controls. 於 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 (頁 6126-6129). [5627802] (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10). https://doi.org/10.1109/IEMBS.2010.5627702
Yin, Tang Kai ; Chiu, Nan-Tsing ; Pai, Ming-Chyi. / Grouping a few sets of normally distributed voxels of SPECT volumes in discrimination between alzheimer dementia and controls. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. 頁 6126-6129 (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10).
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Yin, TK, Chiu, N-T & Pai, M-C 2010, Grouping a few sets of normally distributed voxels of SPECT volumes in discrimination between alzheimer dementia and controls. 於 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10., 5627802, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, 頁 6126-6129, 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, Buenos Aires, Argentina, 10-08-31. https://doi.org/10.1109/IEMBS.2010.5627702

Grouping a few sets of normally distributed voxels of SPECT volumes in discrimination between alzheimer dementia and controls. / Yin, Tang Kai; Chiu, Nan-Tsing; Pai, Ming-Chyi.

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 6126-6129 5627802 (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10).

研究成果: Conference contribution

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Yin TK, Chiu N-T, Pai M-C. Grouping a few sets of normally distributed voxels of SPECT volumes in discrimination between alzheimer dementia and controls. 於 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 6126-6129. 5627802. (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10). https://doi.org/10.1109/IEMBS.2010.5627702