Ha-ras Oncogene and Anticancer Drug Resistance

Giri Raghavaraju, Hsiao Sheng Liu

研究成果: Review article

1 引文 (Scopus)

摘要

Extensive research on the Ras proteins and their functions in cell physiology over the past 30 years has led to copious approaches that reported the possible role of Ras not only in tumorigenesis but also in many developmental disorders. One of the hallmarks of human cancers is the intrinsic resistance to apoptosis. In this review we focus on anticancer drug sensitivities towards Ha- ras oncogene overexpression in vitro, reveal the downstream Ras effector molecules involved in the signaling pathways and the effect on cell cycle progression. Furthermore, we particularly emphasized 5-fluorouracil, Lovastatin, Tumor necrosis factor-α and Xanthone in selective suppression of Ha- ras-related tumorigenesis. Hence, a better understanding of the molecular mechanisms underlying tumor sensitivity to apoptotic cell death is anticipated to provide the basis for a rational approach to develop molecular targeted therapies.

原文English
頁(從 - 到)39-48
頁數10
期刊Genomic Medicine, Biomarkers, and Health Sciences
3
發行號1
DOIs
出版狀態Published - 2011 九月 26

指紋

ras Proteins
Lovastatin
ras Genes
Physiology
Cell death
Drug Resistance
Fluorouracil
Tumors
Carcinogenesis
Tumor Necrosis Factor-alpha
Cells
Molecular Targeted Therapy
Apoptosis
Cell Physiological Phenomena
Molecules
Pharmaceutical Preparations
Neoplasms
Cell Cycle
Cell Death
Proteins

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biochemistry, Genetics and Molecular Biology(all)
  • Drug Discovery

引用此文

Raghavaraju, Giri ; Liu, Hsiao Sheng. / Ha-ras Oncogene and Anticancer Drug Resistance. 於: Genomic Medicine, Biomarkers, and Health Sciences. 2011 ; 卷 3, 編號 1. 頁 39-48.
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Ha-ras Oncogene and Anticancer Drug Resistance. / Raghavaraju, Giri; Liu, Hsiao Sheng.

於: Genomic Medicine, Biomarkers, and Health Sciences, 卷 3, 編號 1, 26.09.2011, p. 39-48.

研究成果: Review article

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