Hemostatic molecular markers in nephrotic syndrome

Tsai-Yun Chen, Chieng‐Chung ‐C Huang, Chao‐Jung ‐J Tsao

研究成果: Article同行評審

28 引文 斯高帕斯(Scopus)


Quantitative changes of hemostatic molecular markers were studied in patients with nephrotic syndrome. The plasma levels of fibrinopeptide A (FPA), thrombin‐antithrombin III complex (TAT), products of thrombin activation, and fragment F1 + 2 (F1 + 2), a product of prothrombin activation, were measured by enzyme immunoassay in 21 patients with nephrotic syndrome and in 16 normal controls. The mean value of FPA was 17.5 ± 7.5 ng/ml (mean ± SD) in nephrotic patients and 4.5 ± 0.3 ng/ml in normal controls (P < 0.02); F1 + 2 concentration was 1.4 ± 0.3 ng/ml in nephrotic patients and 0.5 ± 0.1 ng/ml in normal controls (P < 0.001); TAT level was 1.0 ± 0.3 μg/l in nephrotic patients and 0.2 ± 0.1 μg/l in normal controls (P < 0.05). These data indicated intravascular hemostasis activation. Based on these results, we propose that low antithrombin III level in nephrotic patients may be due to both urinary loss and intravascular consumption. © 1993 Wiley‐Liss, Inc.

頁(從 - 到)276-279
期刊American Journal of Hematology
出版狀態Published - 1993 1月 1

All Science Journal Classification (ASJC) codes

  • 血液學


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