Hepatoma-derived growth factor supports the antiapoptosis and profibrosis of pancreatic stellate cells

Yi Ting Chen, Feng Wei Chen, Tsung Hao Chang, Tso Wen Wang, Teng Po Hsu, Jhih Ying Chi, Yu Wei Hsiao, Chien Feng Li, Ju-Ming Wang

研究成果: Article

摘要

Pancreatic cancer is refractory and is characterized by extensively surrounding and intratumor fibrotic reactions that are contributed by activated pancreatic stellate cells (PSCs). Herein, we show that CCAAT/enhancer-binding protein δ (CEBPD) responds to transforming growth factor-β1 (TGF-β1) through reciprocal loop regulation and that activated hypoxia inducible factor-1α (HIF-1α) further contributes to the upregulation of the hepatoma-derived growth factor (HDGF) gene. Secreted HDGF contributes to the antiapoptosis of PSCs and consequently leads to the synthesis and deposition of extracellular matrix proteins for stabilizing PSC/pancreatic cancer cell (PCC) tumor foci. This result agrees with the observation that severe stromal growth positively correlated with stromal HDGF and CEBPD expression in pancreatic cancer specimens. Collectively, the identification of the TGF-β1-activated CEBPD/HIF-1α/HDGF axis provides new insights into novel discoveries of HDGF in the antiapoptosis and profibrosis of PSCs and the outgrowth of PCCs.

原文English
頁(從 - 到)180-190
頁數11
期刊Cancer Letters
457
DOIs
出版狀態Published - 2019 八月 10

指紋

Pancreatic Stellate Cells
Pancreatic Neoplasms
Hypoxia-Inducible Factor 1
Transforming Growth Factors
CCAAT-Enhancer-Binding Proteins
Extracellular Matrix Proteins
Up-Regulation
hepatoma-derived growth factor
Growth
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

引用此文

Chen, Yi Ting ; Chen, Feng Wei ; Chang, Tsung Hao ; Wang, Tso Wen ; Hsu, Teng Po ; Chi, Jhih Ying ; Hsiao, Yu Wei ; Li, Chien Feng ; Wang, Ju-Ming. / Hepatoma-derived growth factor supports the antiapoptosis and profibrosis of pancreatic stellate cells. 於: Cancer Letters. 2019 ; 卷 457. 頁 180-190.
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Hepatoma-derived growth factor supports the antiapoptosis and profibrosis of pancreatic stellate cells. / Chen, Yi Ting; Chen, Feng Wei; Chang, Tsung Hao; Wang, Tso Wen; Hsu, Teng Po; Chi, Jhih Ying; Hsiao, Yu Wei; Li, Chien Feng; Wang, Ju-Ming.

於: Cancer Letters, 卷 457, 10.08.2019, p. 180-190.

研究成果: Article

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AU - Hsu, Teng Po

AU - Chi, Jhih Ying

AU - Hsiao, Yu Wei

AU - Li, Chien Feng

AU - Wang, Ju-Ming

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