Hepatoprotective principles and other chemical constituents from the mycelium of Phellinus linteus

Shiow Chyn Huang, Pei Wen Wang, Ping Chung Kuo, Hsin Yi Hung, Tai Long Pan

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)

摘要

In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D–N (4–14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.

原文English
文章編號1705
期刊Molecules
23
發行號7
DOIs
出版狀態Published - 2018

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 化學(雜項)
  • 分子醫學
  • 藥學科學
  • 藥物發現
  • 物理與理論化學
  • 有機化學

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