HER-2 antibody conjugated gold nano rod particles for in vivo photothermal therapy

Ann Ann Ding, Ying Yi Chen, Ren Chris Churng-Wang, Pai Chi Li, Dar-Bin Shieh

研究成果: Conference contribution

4 引文 斯高帕斯(Scopus)

摘要

Recent studies reported gold nano rod (AuNRs) exhibit surface plasmonic resonance frequency (SPR) proportional to their aspect ratio. The interaction of AuNRs with electromagnetic radiation corresponding to their SPR could generate local regional heat. With precise control of the aspect ratio, AuNR could interact with near-infrared (NIR) laser light in the biological optical window that best penetrate human tissues to optimize hyperthermia therapy [1]. We exploit AuNRs to conjugate HER-2 antibodies specific for targeting tumor cells. HER-2 was reported to be associated with disease prognosis and clinical theray [2] and was reported to be over-expressed in many types of cancer. In this study, AuNRs was found to present high bio-compatibility and hemo-compatibility. In vitro laser induced hyperthermia study revealed a selective damage of OECM-1 cancer cells targeted by the AuNR probe. We discovered only the use of AuNR combined correct laser wavelength corresponding to SPR of the AuNR could induce effective hyperthermia therapy. In vivo model using tumor bearing SCID mice, an increase in tumor local temperature and improved therapeutic results were discovered in the AuNRs-HER2 treatment group compared to that of AuNRs alone. In conclusion, HER-2 antibodies conjugated AuNR combined NIR laser could be a potent modality in cancer targeting therapy that could minimize side effects attribute to the nanoscale precision of high temperature delivery. Besides, AuNRs showed a tunable SPR within NIR range could be applied for multiplex photo-thermal effect and combined multiple target photo-acoustic molecular imaging for combined diagnosis and therapy in a single platform.

原文English
主出版物標題2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
頁面882-885
頁數4
DOIs
出版狀態Published - 2008 十一月 10
事件2008 8th IEEE Conference on Nanotechnology, IEEE-NANO - Arlington, TX, United States
持續時間: 2008 八月 182008 八月 21

出版系列

名字2008 8th IEEE Conference on Nanotechnology, IEEE-NANO

Other

Other2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
國家United States
城市Arlington, TX
期間08-08-1808-08-21

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

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    Ding, A. A., Chen, Y. Y., Churng-Wang, R. C., Li, P. C., & Shieh, D-B. (2008). HER-2 antibody conjugated gold nano rod particles for in vivo photothermal therapy. 於 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO (頁 882-885). [4617246] (2008 8th IEEE Conference on Nanotechnology, IEEE-NANO). https://doi.org/10.1109/NANO.2008.264