Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice

Hung Ming Wu, Chiung Chun Huang, Shun-hua Chen, Ying Ching Liang, Jing Jane Tsai, Ching Liang Hsieh, Kuei-Sen Hsu

研究成果: Article

34 引文 斯高帕斯(Scopus)


Herpes simplex virus type 1 (HSV-1) is the major pathogen related to epilepsy. However, little is known about the pathogenesis of HSV-1-associated epilepsy. Here, we report that corneal inoculation of mice with HSV-1 induces acute spontaneous behavioural and electrophysiological seizures and chronically increases hippocampal excitability and seizure susceptibility. In slices from infected mice, the surviving hippocampal CA3 pyramidal neurons exhibited a more depolarizing resting membrane potential concomitant with an increase in membrane input resistance. They also had a lower threshold for generating synchronized bursts and a decrease in the amplitude of afterhyperpolarization (AHP) than did controls. These results suggest that a direct change in the excitability of the hippocampal CA3 neuronal network could play an important role in facilitating the development of acute seizures and subsequent epilepsy.

頁(從 - 到)3294-3304
期刊European Journal of Neuroscience
出版狀態Published - 2003 十二月


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)