Hidradenitis suppurativa: Disease pathophysiology and sex hormones

Chia Bao Chu, Chao Chun Yang, Shaw Jenq Tsai

研究成果: Review article同行評審

7 引文 斯高帕斯(Scopus)


Hidradenitis suppurativa is a cutaneous chronic inflammatory disease that is estimated to affect about 1% of the population and caused pain, malodorous discharge, disfigurement, and poor quality of life with psychosocial problems. The typical features are recurrent painful nodules, abscesses, and sinus tracts on the axillae, groins, gluteal areas, and anogenital regions since postpuberty. Smoking and obesity are two major triggering factors of hidradenitis suppurativa. Women are prone to have hidradenitis suppurativa than men in Western countries, but the male-to-female ratio is reversed in oriental countries. The disease severity can be affected by menstruation, pregnancy, and menopause. Furthermore, the phenotypes are different among men and women with hidradenitis suppurativa. Men are prone to have buttock involvement while women are prone to have axillary, groins, and submammary lesions. This review introduces the skin appendages and pathophysiology of hidradenitis suppurativa and then focuses on the sex difference and the effects of sex hormones on hidradenitis suppurativa and current hormone-associated treatments.

頁(從 - 到)257-265
期刊Chinese Journal of Physiology
出版狀態Published - 2021 11月 1

All Science Journal Classification (ASJC) codes

  • 生理學
  • 生理學(醫學)


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