High-Incidence of Human Adenoviral Co-Infections in Taiwan

Shan Li Wang, Chia Yu Chi, Pin Hwa Kuo, Huey Pin Tsai, Shih-Min Wang, Ching-Chuan Liu, Ih Jen Su, Jen-Ren Wang

研究成果: Article

18 引文 (Scopus)

摘要

Background:Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan.Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the past decade.Study Design:One hundred and twenty-six human adenoviruses, isolated between 2002 to 2011, were characterized via DNA sequencing of the hexon and fiber genes. The nucleotide sequences were then compared by phylogenetic analysis.Results:HAdV-B3 accounted for 64.3% (81/126) and peaked almost every year, whereas the sequences of hexon and fiber genes of HAdV-B3 were highly conserved in different years. A high incidence of co-infection of adenoviruses was observed (19.0%, 24/126); HAdV-B3 co-infected with HAdV-C2 was the most common combination (58.3%, 14/24). An additional interesting finding of repeated infection was noted in 10 children, all of whom showed first infection with adenovirus species HAdV-C, followed by species HAdV-B or HAdV-E.Conclusions:HAdV-B3 was the predominant type of respiratory adenovirus circulating in Taiwan over the past ten years. This merits further attention for vaccine development. Furthermore, the observed high-incidence of adenoviral co-infections along with repeated infections found in our study provides important epidemiological insights into adenovirus infections.

原文English
文章編號e75208
期刊PLoS ONE
8
發行號9
DOIs
出版狀態Published - 2013 九月 20

指紋

Adenoviridae
Coinfection
mixed infection
Taiwan
Genes
Adenoviridae Infections
incidence
Fibers
Incidence
infection
Vaccines
Nucleotides
Infection
Human adenovirus E
Human Adenoviruses
Human adenovirus B
Molecular Epidemiology
DNA
Human adenovirus C
DNA Sequence Analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

引用此文

Wang, Shan Li ; Chi, Chia Yu ; Kuo, Pin Hwa ; Tsai, Huey Pin ; Wang, Shih-Min ; Liu, Ching-Chuan ; Su, Ih Jen ; Wang, Jen-Ren. / High-Incidence of Human Adenoviral Co-Infections in Taiwan. 於: PLoS ONE. 2013 ; 卷 8, 編號 9.
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abstract = "Background:Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan.Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the past decade.Study Design:One hundred and twenty-six human adenoviruses, isolated between 2002 to 2011, were characterized via DNA sequencing of the hexon and fiber genes. The nucleotide sequences were then compared by phylogenetic analysis.Results:HAdV-B3 accounted for 64.3{\%} (81/126) and peaked almost every year, whereas the sequences of hexon and fiber genes of HAdV-B3 were highly conserved in different years. A high incidence of co-infection of adenoviruses was observed (19.0{\%}, 24/126); HAdV-B3 co-infected with HAdV-C2 was the most common combination (58.3{\%}, 14/24). An additional interesting finding of repeated infection was noted in 10 children, all of whom showed first infection with adenovirus species HAdV-C, followed by species HAdV-B or HAdV-E.Conclusions:HAdV-B3 was the predominant type of respiratory adenovirus circulating in Taiwan over the past ten years. This merits further attention for vaccine development. Furthermore, the observed high-incidence of adenoviral co-infections along with repeated infections found in our study provides important epidemiological insights into adenovirus infections.",
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High-Incidence of Human Adenoviral Co-Infections in Taiwan. / Wang, Shan Li; Chi, Chia Yu; Kuo, Pin Hwa; Tsai, Huey Pin; Wang, Shih-Min; Liu, Ching-Chuan; Su, Ih Jen; Wang, Jen-Ren.

於: PLoS ONE, 卷 8, 編號 9, e75208, 20.09.2013.

研究成果: Article

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AB - Background:Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan.Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the past decade.Study Design:One hundred and twenty-six human adenoviruses, isolated between 2002 to 2011, were characterized via DNA sequencing of the hexon and fiber genes. The nucleotide sequences were then compared by phylogenetic analysis.Results:HAdV-B3 accounted for 64.3% (81/126) and peaked almost every year, whereas the sequences of hexon and fiber genes of HAdV-B3 were highly conserved in different years. A high incidence of co-infection of adenoviruses was observed (19.0%, 24/126); HAdV-B3 co-infected with HAdV-C2 was the most common combination (58.3%, 14/24). An additional interesting finding of repeated infection was noted in 10 children, all of whom showed first infection with adenovirus species HAdV-C, followed by species HAdV-B or HAdV-E.Conclusions:HAdV-B3 was the predominant type of respiratory adenovirus circulating in Taiwan over the past ten years. This merits further attention for vaccine development. Furthermore, the observed high-incidence of adenoviral co-infections along with repeated infections found in our study provides important epidemiological insights into adenovirus infections.

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