摘要
Background:Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan.Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the past decade.Study Design:One hundred and twenty-six human adenoviruses, isolated between 2002 to 2011, were characterized via DNA sequencing of the hexon and fiber genes. The nucleotide sequences were then compared by phylogenetic analysis.Results:HAdV-B3 accounted for 64.3% (81/126) and peaked almost every year, whereas the sequences of hexon and fiber genes of HAdV-B3 were highly conserved in different years. A high incidence of co-infection of adenoviruses was observed (19.0%, 24/126); HAdV-B3 co-infected with HAdV-C2 was the most common combination (58.3%, 14/24). An additional interesting finding of repeated infection was noted in 10 children, all of whom showed first infection with adenovirus species HAdV-C, followed by species HAdV-B or HAdV-E.Conclusions:HAdV-B3 was the predominant type of respiratory adenovirus circulating in Taiwan over the past ten years. This merits further attention for vaccine development. Furthermore, the observed high-incidence of adenoviral co-infections along with repeated infections found in our study provides important epidemiological insights into adenovirus infections.
| 原文 | English |
|---|---|
| 文章編號 | e75208 |
| 期刊 | PLoS ONE |
| 卷 | 8 |
| 發行號 | 9 |
| DOIs | |
| 出版狀態 | Published - 2013 九月 20 |
指紋
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
引用此文
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High-Incidence of Human Adenoviral Co-Infections in Taiwan. / Wang, Shan Li; Chi, Chia Yu; Kuo, Pin Hwa; Tsai, Huey Pin; Wang, Shih-Min; Liu, Ching-Chuan; Su, Ih Jen; Wang, Jen-Ren.
於: PLoS ONE, 卷 8, 編號 9, e75208, 20.09.2013.研究成果: Article
TY - JOUR
T1 - High-Incidence of Human Adenoviral Co-Infections in Taiwan
AU - Wang, Shan Li
AU - Chi, Chia Yu
AU - Kuo, Pin Hwa
AU - Tsai, Huey Pin
AU - Wang, Shih-Min
AU - Liu, Ching-Chuan
AU - Su, Ih Jen
AU - Wang, Jen-Ren
PY - 2013/9/20
Y1 - 2013/9/20
N2 - Background:Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan.Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the past decade.Study Design:One hundred and twenty-six human adenoviruses, isolated between 2002 to 2011, were characterized via DNA sequencing of the hexon and fiber genes. The nucleotide sequences were then compared by phylogenetic analysis.Results:HAdV-B3 accounted for 64.3% (81/126) and peaked almost every year, whereas the sequences of hexon and fiber genes of HAdV-B3 were highly conserved in different years. A high incidence of co-infection of adenoviruses was observed (19.0%, 24/126); HAdV-B3 co-infected with HAdV-C2 was the most common combination (58.3%, 14/24). An additional interesting finding of repeated infection was noted in 10 children, all of whom showed first infection with adenovirus species HAdV-C, followed by species HAdV-B or HAdV-E.Conclusions:HAdV-B3 was the predominant type of respiratory adenovirus circulating in Taiwan over the past ten years. This merits further attention for vaccine development. Furthermore, the observed high-incidence of adenoviral co-infections along with repeated infections found in our study provides important epidemiological insights into adenovirus infections.
AB - Background:Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan.Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the past decade.Study Design:One hundred and twenty-six human adenoviruses, isolated between 2002 to 2011, were characterized via DNA sequencing of the hexon and fiber genes. The nucleotide sequences were then compared by phylogenetic analysis.Results:HAdV-B3 accounted for 64.3% (81/126) and peaked almost every year, whereas the sequences of hexon and fiber genes of HAdV-B3 were highly conserved in different years. A high incidence of co-infection of adenoviruses was observed (19.0%, 24/126); HAdV-B3 co-infected with HAdV-C2 was the most common combination (58.3%, 14/24). An additional interesting finding of repeated infection was noted in 10 children, all of whom showed first infection with adenovirus species HAdV-C, followed by species HAdV-B or HAdV-E.Conclusions:HAdV-B3 was the predominant type of respiratory adenovirus circulating in Taiwan over the past ten years. This merits further attention for vaccine development. Furthermore, the observed high-incidence of adenoviral co-infections along with repeated infections found in our study provides important epidemiological insights into adenovirus infections.
UR - http://www.scopus.com/inward/record.url?scp=84884490538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884490538&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0075208
DO - 10.1371/journal.pone.0075208
M3 - Article
C2 - 24073254
AN - SCOPUS:84884490538
VL - 8
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 9
M1 - e75208
ER -