High prevalence of metabolic disturbances in patients with bipolar disorder in Taiwan

Hui Hua Chang, Chen Hsi Chou, Po See Chen, Po Wu Gean, Hui Chun Huang, Chia Yin Lin, Yen Kuang Yang, Ru Band Lu

研究成果: Article同行評審

56 引文 斯高帕斯(Scopus)


Background: Both ethnicity and lifestyle may contribute to these abnormalities. High prevalences of obesity and metabolic disturbances in patients with bipolar disorder (BD) have been reported in western countries. However, reports about the prevalences in Asian countries remain scant. Method: The cross-sectional study included 117 patients diagnosed as BD and treated with lithium (Li), valproate (VPA), or both at a university psychiatric outpatient clinic. Their body mass index and plasma levels of glucose and lipid were measured. The prevalence of metabolic syndrome was determined based on the IDF 2005 criteria. Results: 13.7%, 36.8%, 53.0%, 18.6%, and 61.0% of the patients met the criteria for hyperglycemia, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), hypertension and large waist circumference, respectively. 33.9% of the patients met the IDF 2005 criterion for metabolic syndrome. The prevalence of metabolic abnormalities was significantly higher in patients who have been cotreated with second-generation antipsychotics (SGAs). Conclusion: This study provides evidence of high prevalence of metabolic syndrome in BD patients in Taiwan. Such metabolic disturbances can increase morbidity and mortality. Further studies that focus on the underlying mechanisms and effective intervention strategies are warranted.

頁(從 - 到)124-129
期刊Journal of Affective Disorders
出版狀態Published - 2009 九月

All Science Journal Classification (ASJC) codes

  • 臨床心理學
  • 精神病學和心理健康


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