High prevalence of SV40 infection in patients with nodal non-Hodgkin's lymphoma but not acute leukemia independent of contaminated polio vaccines in Taiwan

Po Min Chen, Chueh Chuan Yen, Muh Hwa Yang, Say Bee Poh, Liang Tsai Hsiao, Wei Shu Wang, Peng Chan Lin, Ming Yang Lee, Hao Wei Teng, Li Yuan Bai, Chiau Jun Chu, Shu Chauo Chao, An Hang Yang, Tzeon Jye Chiou, Jin Hwang Liu, Ta Chung Chao

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

Recent studies have linked simian virus 40 (SV40) to non-Hodgkin's lymphoma (NHL), especially in countries in which people were exposed to contaminated polio vaccines prior to 1963. In Taiwan, nearly all children were not exposed to contaminated polio vaccine during this period; the relationship between SV40 infection and hematological malignancies is unclear and deserves to be studied. Using PCR amplification of SV40 large T antigen DNA, confirmed by Southern blot hybridization and sequence analysis, 91 frozen lymph nodes from NHL patients were examined. Thirteen (14.3 percent) showed positive for SV40. All other test samples, including diagnostic bone marrow from patients with acute leukemia, peripheral blood from 10 relatives of SV40 positive-patients and 91 age-matched normal volunteers, and 5 reactive hyperplastic lymphoid tissues, showed negative. These results may reflect that human-to-human transmission of SV40 is independent of contaminated polio vaccines; and SV40 is possibly associated with the development of NHL in Taiwan (p = 0.0001). Prospective studies are needed to determine the prevalence of SV40 infections in our and other human populations and to explore the means of transmission of the virus.

原文English
頁(從 - 到)223-228
頁數6
期刊Cancer Investigation
24
發行號3
DOIs
出版狀態Published - 2006 五月 1

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究

指紋

深入研究「High prevalence of SV40 infection in patients with nodal non-Hodgkin's lymphoma but not acute leukemia independent of contaminated polio vaccines in Taiwan」主題。共同形成了獨特的指紋。

引用此