TY - JOUR
T1 - High rates of antimicrobial resistance among clinical isolates of nontyphoidal Salmonella in Taiwan
AU - Yang, Y. J.
AU - Liu, C. C.
AU - Wang, S. M.
AU - Wu, J. J.
AU - Huang, A. H.
AU - Cheng, C. P.
N1 - Funding Information:
Acknowledgements This study was supported by grants from the National Health Research Institutes, Taiwan (AD01-86RE-01), and the National Cheng Kung University Hospital, Taiwan (NCKUH-88-026). The authors are grateful to Dr. Kun-yen Huang for his critical review and suggestions for improvement of this manuscript.
PY - 1998
Y1 - 1998
N2 - To assess trends in antimicrobial-resistant Salmonella infections from 1989 to 1996 in southern Taiwan, the minimum inhibitory concentrations (MICs) of 14 antibiotics or antibiotic combinations were determined by the agar dilution method for 297 clinical isolates of nontyphoidal Salmonella. The rates of resistance to ampicillin, chloramphenicol, and tetracycline were 65, 67, and 78%, respectively. Resistance to trimethoprim-sulfamethoxazole (TMP-SMX) increased from 25% in 1989-1992 to 35% in 1993-1996 (P = 0.057). For new quinolones and extended-spectrum cephalosporins, no resistant strains were encountered. Multiple resistance to more than five antimicrobial drugs doubled from 10.6% in 1989-1992 to 19.7% in 1993-1996. Multiple resistant salmonellae were isolated more commonly from blood samples than from feces (30% vs. 14%, P < 0.05). In Taiwan, ampicillin, chloramphenicol, and even TMP-SMX are no longer the drugs of choice for treatment of serious nontyphoidal Salmonella infections. Extended-spectrum cephalosporins are now the preferred drugs in Taiwan for treatment of invasive Salmonella infections in children.
AB - To assess trends in antimicrobial-resistant Salmonella infections from 1989 to 1996 in southern Taiwan, the minimum inhibitory concentrations (MICs) of 14 antibiotics or antibiotic combinations were determined by the agar dilution method for 297 clinical isolates of nontyphoidal Salmonella. The rates of resistance to ampicillin, chloramphenicol, and tetracycline were 65, 67, and 78%, respectively. Resistance to trimethoprim-sulfamethoxazole (TMP-SMX) increased from 25% in 1989-1992 to 35% in 1993-1996 (P = 0.057). For new quinolones and extended-spectrum cephalosporins, no resistant strains were encountered. Multiple resistance to more than five antimicrobial drugs doubled from 10.6% in 1989-1992 to 19.7% in 1993-1996. Multiple resistant salmonellae were isolated more commonly from blood samples than from feces (30% vs. 14%, P < 0.05). In Taiwan, ampicillin, chloramphenicol, and even TMP-SMX are no longer the drugs of choice for treatment of serious nontyphoidal Salmonella infections. Extended-spectrum cephalosporins are now the preferred drugs in Taiwan for treatment of invasive Salmonella infections in children.
UR - http://www.scopus.com/inward/record.url?scp=0032423764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032423764&partnerID=8YFLogxK
U2 - 10.1007/s100960050213
DO - 10.1007/s100960050213
M3 - Article
C2 - 10052556
AN - SCOPUS:0032423764
SN - 0934-9723
VL - 17
SP - 880
EP - 883
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 12
ER -
