High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants

Sun Ma, Lih Ing Shieh, Chao Ching Huang

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

High-resolution proton nuclear magnetic resonance spectroscopy was used to study human urine obtained from 10 normal babies and twenty babies with various degrees of neonatal asphyxia, respiratory distress syndrome (RDS), and meconium aspiration syndrome (MAS). All sick babies showed different degrees of oxygen deficiency, indicated by an obvious increase of the lactate signal level in the urine spectra. Changes in the concentration of other urinary metabolites produced from the citric acid cycle were also observed. In extremely serious cases, the signals of some of the major components, including citrate, α-ketoglutarate, and succinate, simply disappeared. The spectra of urine, serum, and CSF of an infant suffering from SIDS showed common characteristics of the metabolites.

原文English
頁(從 - 到)37-51
頁數15
期刊Applied Biochemistry and Biotechnology
53
發行號1
DOIs
出版狀態Published - 1995 四月

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 生物工程
  • 生物化學
  • 應用微生物與生物技術
  • 分子生物學

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