High-resolution shear wave imaging of the human cornea using a dual-element transducer

Pei Yu Chen, Cho Chiang Shih, Wei-Chen Lin, Teng Ma, Qifa Zhou, K. Kirk Shung, Chih-Chung Huang

研究成果: Article

1 引文 (Scopus)

摘要

Estimating the corneal elasticity can provide valuable information for corneal pathologies and treatments. Ophthalmologic pathologies will invariably cause changes to the elasticity of the cornea. For example, keratoconus and the phototoxic effects of ultraviolet radiation usually increase the corneal elasticity. This makes a quantitative estimation of the elasticity of the human cornea important for ophthalmic diagnoses. The present study investigated the use of a proposed high-resolution shear wave imaging (HR-SWI) method based on a dual-element transducer (comprising an 8-MHz element for pushing and a 32-MHz element for imaging) for measuring the group shear wave velocity (GSWV) of the human cornea. An empirical Young’s modulus formula was used to accurately convert the GSWV to Young’s modulus. Four quantitative parameters, bias, resolution, contrast, and contrast-to-noise ratio (CNR), were measured in gelatin phantoms with two different concentrations (3% and 7%) to evaluate the performance of HR-SWI. The biases of gelatin phantoms (3% and 7%) were 5.88% and 0.78%, respectively. The contrast and CNR were 0.76, 1.31 and 3.22, 2.43 for the two-side and two-layer phantoms, respectively. The measured image resolutions of HR-SWI in the lateral and axial directions were 72 and 140 µm, respectively. The calculated phase SWV (PSWV) and their corresponding Young’s modulus from six human donors were 2.45 ± 0.48 m/s (1600 Hz) and 11.52 ± 7.81 kPa, respectively. All the experimental results validated the concept of HR-SWI and its ability for measuring the human corneal elasticity.

原文English
文章編號4244
期刊Sensors (Switzerland)
18
發行號12
DOIs
出版狀態Published - 2018 十二月 1

指紋

cornea
Shear waves
Elasticity
Transducers
Cornea
S waves
transducers
Elastic Modulus
Imaging techniques
elastic properties
high resolution
Gelatin
modulus of elasticity
Elastic moduli
gelatins
pathology
Pathology
Noise
Keratoconus
Radiation Effects

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Biochemistry
  • Instrumentation
  • Electrical and Electronic Engineering

引用此文

Chen, Pei Yu ; Shih, Cho Chiang ; Lin, Wei-Chen ; Ma, Teng ; Zhou, Qifa ; Shung, K. Kirk ; Huang, Chih-Chung. / High-resolution shear wave imaging of the human cornea using a dual-element transducer. 於: Sensors (Switzerland). 2018 ; 卷 18, 編號 12.
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abstract = "Estimating the corneal elasticity can provide valuable information for corneal pathologies and treatments. Ophthalmologic pathologies will invariably cause changes to the elasticity of the cornea. For example, keratoconus and the phototoxic effects of ultraviolet radiation usually increase the corneal elasticity. This makes a quantitative estimation of the elasticity of the human cornea important for ophthalmic diagnoses. The present study investigated the use of a proposed high-resolution shear wave imaging (HR-SWI) method based on a dual-element transducer (comprising an 8-MHz element for pushing and a 32-MHz element for imaging) for measuring the group shear wave velocity (GSWV) of the human cornea. An empirical Young’s modulus formula was used to accurately convert the GSWV to Young’s modulus. Four quantitative parameters, bias, resolution, contrast, and contrast-to-noise ratio (CNR), were measured in gelatin phantoms with two different concentrations (3{\%} and 7{\%}) to evaluate the performance of HR-SWI. The biases of gelatin phantoms (3{\%} and 7{\%}) were 5.88{\%} and 0.78{\%}, respectively. The contrast and CNR were 0.76, 1.31 and 3.22, 2.43 for the two-side and two-layer phantoms, respectively. The measured image resolutions of HR-SWI in the lateral and axial directions were 72 and 140 µm, respectively. The calculated phase SWV (PSWV) and their corresponding Young’s modulus from six human donors were 2.45 ± 0.48 m/s (1600 Hz) and 11.52 ± 7.81 kPa, respectively. All the experimental results validated the concept of HR-SWI and its ability for measuring the human corneal elasticity.",
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High-resolution shear wave imaging of the human cornea using a dual-element transducer. / Chen, Pei Yu; Shih, Cho Chiang; Lin, Wei-Chen; Ma, Teng; Zhou, Qifa; Shung, K. Kirk; Huang, Chih-Chung.

於: Sensors (Switzerland), 卷 18, 編號 12, 4244, 01.12.2018.

研究成果: Article

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