High-speed label-free functional photoacoustic microscopy of mouse brain in action

Junjie Yao, Lidai Wang, Joon Mo Yang, Konstantin I. Maslov, Terence T.W. Wong, Lei Li, Chih Hsien Huang, Jun Zou, Lihong V. Wang

研究成果: Article同行評審

418 引文 斯高帕斯(Scopus)

摘要

We present fast functional photoacoustic microscopy (PAM) for three-dimensional high-resolution, high-speed imaging of the mouse brain, complementary to other imaging modalities. We implemented a single-wavelength pulse-width-based method with a one-dimensional imaging rate of 100 kHz to image blood oxygenation with capillary-level resolution. We applied PAM to image the vascular morphology, blood oxygenation, blood flow and oxygen metabolism in both resting and stimulated states in the mouse brain.

原文English
頁(從 - 到)407-410
頁數4
期刊Nature Methods
12
發行號5
DOIs
出版狀態Published - 2015 四月 29

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 生物化學
  • 分子生物學
  • 細胞生物學

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