Histopathological Study on Collagen in Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei)

Chen Yi Su, Tzu Yu Liu, Hao Ven Wang, Wei Cheng Yang

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Fraser’s dolphins (Lagenodelphis hosei) possess great healing abilities. Their skin composition can be restored after wounding, including collagen spacing, orientation, and bundle thickness. However, it remains unclear how collagens are involved in the wound-healing process and eventually regain normality in Fraser’s dolphins. Learned from the other two scarless healing animals, changes in type III/I collagen composition are believed to modulate the wound healing process and influence the scarring or scarless fate determination in human fetal skin and spiny mouse skin. In the current study, Herovici’s, trichrome, and immunofluorescence staining were used on normal and wounded skin samples in Fraser’s dolphins. The results suggested that type I collagens were the main type of collagens in the normal skin of Fraser’s dolphins, while type III collagens were barely seen. During the wound healing process, type III collagens showed at early wound healing stages, and type I collagen increased in the mature healed wound. In an early healed wound, collagens were organized in a parallel manner, showing a transient hypertrophic-like scar, and eventually restored to normal collagen configuration and adipocyte distribution in the mature healed wound. The remarkable ability to remove excessive collagens merits further investigation to provide new insights into clinical wound management.

原文English
文章編號1681
期刊Animals
13
發行號10
DOIs
出版狀態Published - 2023 5月

All Science Journal Classification (ASJC) codes

  • 動物科學與動物學
  • 一般獸醫學

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