Honeycomb-shaped magnetic multilayer thin films for cell trapping

Chen Yu Huang, Wei Chieh Chang, Kun Chieh Yeh, Han Yi Tseng, Ming Shinn Hsu, Jiann Yeu Chen, Zung Hang Wei

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Honeycomb-shaped magnetic thin films with domain wall (DW) pinning geometry are designed to actively trap magnetically labeled cells. After an initial in-plane magnetic field (Hinitial) is applied and later reduced to zero, the resultant magnetization became locally aligned. Human hepatocellular liver carcinoma cell line (HepG2) stably expresses green fluorescent protein (GFP) and is magnetically labeled with superparamagnetic magnetic nanoparticles (MNPs). Prussian blue stain and single cell magnetophoresis are performed to evaluate the internalization of the MNPs. Magnetically labeled cells are then trapped by the stray fields of head-to-head DWs (HH DWs) or tail-to-tail DWs (TT DWs). After co-culturing with magnetic structure, HepG2 cells stretched out and showed filopodia-like protrusions to make contact with adjacent cells.

原文English
頁(從 - 到)24299-24303
頁數5
期刊RSC Advances
6
發行號29
DOIs
出版狀態Published - 2016 2月 1

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 化學工程 (全部)

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