摘要
Enterohemorrhagic Escherichia coli (EHEC) induces changes to the intestinal cell cytoskeleton and formation of attaching and effacing lesions, characterized by the effacement of microvilli and then formation of actin pedestals to which the bacteria are tightly attached. Here, we use a Caenorhabditis elegans model of EHEC infection to show that microvillar effacement is mediated by a signalling pathway including mitotic cyclin-dependent kinase 1 (CDK1) and diaphanous-related formin 1 (CYK1). Similar observations are also made using EHEC-infected human intestinal cells in vitro. Our results support the use of C. elegans as a host model for studying attaching and effacing lesions in vivo, and reveal that the CDK1-formin signal axis is necessary for EHEC-induced microvillar effacement.
原文 | English |
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文章編號 | 90 |
期刊 | Nature communications |
卷 | 12 |
發行號 | 1 |
DOIs | |
出版狀態 | Published - 2021 12月 |
All Science Journal Classification (ASJC) codes
- 一般化學
- 一般生物化學,遺傳學和分子生物學
- 一般物理與天文學