Humoral immune responses inhibit the antitumor activities mediated by salmonella enterica serovar choleraesuis

Che Hsin Lee, Chao-Liang Wu, Shun-hua Chen, Ai-Li Shiau

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

Salmonella is a powerful antitumor agent owing to its tumor-targeting potential, antitumor capability, and ability to deliver therapeutic genes. Host factors including innate and adaptive immune responses play roles in Salmonella-induced antitumor activity. An emerging realization from animal models that host immune system responses to Salmonella remains uncertain. Herein, we used naive mice and Salmonella enterica serovar choleraesuis (S. choleraesuis) immunized mice to study the role of humoral immune response in the antitumor activity of S. choleraesuis. When the anti-Salmonella antibody existed, the invasion activity and gene transfer capability of S. choleraesuis were significantly decreased. Adaptive immune response inhibited S. choleraesuis to target the tumor sites in the immunized mice after systemic administration. Tumors in naive mice treated with S. choleraesuis were significantly smaller than those treated with the control vehicle. By contrast, the treatment of S. choleraesuis was not capable of delaying tumor growth and enhancing survival in experimental metastasis models in the immunized mice. Adoptive transfer of immunized serum and knockout mice experiments demonstrated that adaptive immune responses play important roles in the antitumor activity of S. choleraesuis. These findings provide the basis for future studies aiming to modulate the immune response during bacterial therapy.

原文English
頁(從 - 到)376-388
頁數13
期刊Journal of Immunotherapy
32
發行號4
DOIs
出版狀態Published - 2009 5月 1

All Science Journal Classification (ASJC) codes

  • 免疫學
  • 免疫學和過敏
  • 癌症研究
  • 藥理
  • 一般醫學

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