Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection

Fei Wang; Weiwei Gao; Soracha Thamphiwatana; Brian T. Luk; Pavimol Angsantikul; Qiangzhe Zhang; Che Ming J. Hu; Ronnie H. Fang; Jonathan A. Copp; Dissaya Pornpattananangkul; Weiyue Lu; Liangfang Zhang

doi:10.1002/adma.201501071

Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection

Fei Wang
, Weiwei Gao
, Soracha Thamphiwatana
, Brian T. Luk
, Pavimol Angsantikul
, Qiangzhe Zhang
, Che Ming J. Hu
, Ronnie H. Fang
, Jonathan A. Copp
, Dissaya Pornpattananangkul
, Weiyue Lu
, Liangfang Zhang

奈米醫學研究中心

研究成果: Article › 同行評審

132 引文斯高帕斯（Scopus）

摘要

A hybrid nanomaterial integrating unique toxin-absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin-resistant Staphylococcus aureus (MRSA) infection. The hydrogel composition is optimized to retain toxin nanosponges after administration while not compromising toxin transport into the gel for neutralization. Mice treated with the nanosponge-hydrogel hybrid show markedly reduced MRSA skin lesion development.

原文	English
頁（從 - 到）	3437-3443
頁數	7
期刊	Advanced Materials
卷	27
發行號	22
DOIs	https://doi.org/10.1002/adma.201501071
出版狀態	Published - 2015 6月 1

All Science Journal Classification (ASJC) codes

一般材料科學
材料力學
機械工業

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10.1002/adma.201501071

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Wang, F., Gao, W., Thamphiwatana, S., Luk, B. T., Angsantikul, P., Zhang, Q., Hu, C. M. J., Fang, R. H., Copp, J. A., Pornpattananangkul, D., Lu, W., & Zhang, L. (2015). Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection. Advanced Materials, 27(22), 3437-3443. https://doi.org/10.1002/adma.201501071

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abstract = "A hybrid nanomaterial integrating unique toxin-absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin-resistant Staphylococcus aureus (MRSA) infection. The hydrogel composition is optimized to retain toxin nanosponges after administration while not compromising toxin transport into the gel for neutralization. Mice treated with the nanosponge-hydrogel hybrid show markedly reduced MRSA skin lesion development.",

author = "Fei Wang and Weiwei Gao and Soracha Thamphiwatana and Luk, \{Brian T.\} and Pavimol Angsantikul and Qiangzhe Zhang and Hu, \{Che Ming J.\} and Fang, \{Ronnie H.\} and Copp, \{Jonathan A.\} and Dissaya Pornpattananangkul and Weiyue Lu and Liangfang Zhang",

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year = "2015",

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doi = "10.1002/adma.201501071",

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AU - Wang, Fei

AU - Gao, Weiwei

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AU - Luk, Brian T.

AU - Angsantikul, Pavimol

AU - Zhang, Qiangzhe

AU - Hu, Che Ming J.

AU - Fang, Ronnie H.

AU - Copp, Jonathan A.

AU - Pornpattananangkul, Dissaya

AU - Lu, Weiyue

AU - Zhang, Liangfang

PY - 2015/6/1

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AB - A hybrid nanomaterial integrating unique toxin-absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin-resistant Staphylococcus aureus (MRSA) infection. The hydrogel composition is optimized to retain toxin nanosponges after administration while not compromising toxin transport into the gel for neutralization. Mice treated with the nanosponge-hydrogel hybrid show markedly reduced MRSA skin lesion development.

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EP - 3443

JO - Advanced Materials

JF - Advanced Materials

IS - 22

ER -

Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection

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