Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles

Hao Yu Tseng, Chen Yi Lee, Ying Hsia Shih, Xi Zhang Lin, Gwo Bin Lee

研究成果: Conference contribution

4 引文 斯高帕斯(Scopus)

摘要

This paper presents an investigation of hyperthermia cancer therapy utilizing high-frequency magnetic field to induce a temperature increase on tumor cells by using a commercially-available radiography solution containing superparamagnetic nanoparticles. The biocompatible and biodegradable materials allow us to explore hyperthermia cancer therapy in vivo or in vitro. Experimental data showed that a temperature as high as 72.4°C can be successfully generated for in vitro experiments. In-vitro testing showed that survival rate of the tumor cells can be greatly reduced. In-vivo experiments showed that the hyperthermia therapy can significantly repress the growth of liver tumors by utilizing concentrated commercial nanoparticles and temperature-sensitive hydrogel. Hydrogel used in drug delivery system was liquid at low temperature (<20°C) and became gel above 30°C. The gel can be used to secure the nanoparticles in the target tumor tissue. Furthermore, a temperature control system was designed to keep the nanoparticles at a constant temperature such that a reliable cancer therapy can be feasible.

原文English
主出版物標題Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
頁面163-166
頁數4
DOIs
出版狀態Published - 2007 八月 28
事件2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, Thailand
持續時間: 2007 一月 162007 一月 19

出版系列

名字Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Other

Other2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
國家Thailand
城市Bangkok
期間07-01-1607-01-19

All Science Journal Classification (ASJC) codes

  • Computer Networks and Communications
  • Computer Science Applications
  • Electrical and Electronic Engineering

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    Tseng, H. Y., Lee, C. Y., Shih, Y. H., Lin, X. Z., & Lee, G. B. (2007). Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. 於 Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 (頁 163-166). [4160556] (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). https://doi.org/10.1109/NEMS.2007.352253