Identification of yeast cell cycle transcription factors using dynamic system model

研究成果: Conference contribution

摘要

To understand the cell cycle process, it is important to identify the cell cycle transcription factors (TFs) that regulate the expression of cell cycle-regulated genes. We developed a method to identify cell cycle TFs in yeast by integrating current ChIP-chip, mutant, transcription factor binding site (TFBS), and cell cycle gene expression data. We identified 17 cell cycle TFs, 12 of which are known cell cycle TFs, while the remaining five (Ash1, Rlm1, Ste12, Stp1, Tec1) are putative novel cell cycle TFs. Several lines of evidence are provided to verify our predictions. Besides, a high confidence TF-gene regulatory matrix is derived as a byproduct of our method. Moreover, we show that our method performs better than four existing methods for identifying yeast cell cycle TFs. Finally, an application of our method to different cell cycle gene expression datasets suggests that our method is robust.

原文English
主出版物標題2010 IEEE Workshop on Signal Processing Systems, SiPS 2010 - Proceedings
頁面210-215
頁數6
DOIs
出版狀態Published - 2010 十二月 27
事件2010 IEEE Workshop on Signal Processing Systems, SiPS 2010 - San Francisco, CA, United States
持續時間: 2010 十月 62010 十月 8

出版系列

名字IEEE Workshop on Signal Processing Systems, SiPS: Design and Implementation
ISSN(列印)1520-6130

Other

Other2010 IEEE Workshop on Signal Processing Systems, SiPS 2010
國家United States
城市San Francisco, CA
期間10-10-0610-10-08

指紋

Transcription factors
Cell Cycle
Transcription Factor
Yeast
Dynamic Systems
Dynamical systems
Cells
Model
Gene expression
Chip
Genes
Gene
Binding sites
Gene Expression Data
Mutant
Gene Expression
Confidence
Byproducts
Verify

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Signal Processing
  • Applied Mathematics
  • Hardware and Architecture

引用此文

Wu, W-S. (2010). Identification of yeast cell cycle transcription factors using dynamic system model. 於 2010 IEEE Workshop on Signal Processing Systems, SiPS 2010 - Proceedings (頁 210-215). [5624789] (IEEE Workshop on Signal Processing Systems, SiPS: Design and Implementation). https://doi.org/10.1109/SIPS.2010.5624789
Wu, Wei-Sheng. / Identification of yeast cell cycle transcription factors using dynamic system model. 2010 IEEE Workshop on Signal Processing Systems, SiPS 2010 - Proceedings. 2010. 頁 210-215 (IEEE Workshop on Signal Processing Systems, SiPS: Design and Implementation).
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abstract = "To understand the cell cycle process, it is important to identify the cell cycle transcription factors (TFs) that regulate the expression of cell cycle-regulated genes. We developed a method to identify cell cycle TFs in yeast by integrating current ChIP-chip, mutant, transcription factor binding site (TFBS), and cell cycle gene expression data. We identified 17 cell cycle TFs, 12 of which are known cell cycle TFs, while the remaining five (Ash1, Rlm1, Ste12, Stp1, Tec1) are putative novel cell cycle TFs. Several lines of evidence are provided to verify our predictions. Besides, a high confidence TF-gene regulatory matrix is derived as a byproduct of our method. Moreover, we show that our method performs better than four existing methods for identifying yeast cell cycle TFs. Finally, an application of our method to different cell cycle gene expression datasets suggests that our method is robust.",
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Wu, W-S 2010, Identification of yeast cell cycle transcription factors using dynamic system model. 於 2010 IEEE Workshop on Signal Processing Systems, SiPS 2010 - Proceedings., 5624789, IEEE Workshop on Signal Processing Systems, SiPS: Design and Implementation, 頁 210-215, 2010 IEEE Workshop on Signal Processing Systems, SiPS 2010, San Francisco, CA, United States, 10-10-06. https://doi.org/10.1109/SIPS.2010.5624789

Identification of yeast cell cycle transcription factors using dynamic system model. / Wu, Wei-Sheng.

2010 IEEE Workshop on Signal Processing Systems, SiPS 2010 - Proceedings. 2010. p. 210-215 5624789 (IEEE Workshop on Signal Processing Systems, SiPS: Design and Implementation).

研究成果: Conference contribution

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Wu W-S. Identification of yeast cell cycle transcription factors using dynamic system model. 於 2010 IEEE Workshop on Signal Processing Systems, SiPS 2010 - Proceedings. 2010. p. 210-215. 5624789. (IEEE Workshop on Signal Processing Systems, SiPS: Design and Implementation). https://doi.org/10.1109/SIPS.2010.5624789