Ifenprodil for prolonged spinal blockades of motor function and nociception in rats

Yu Wen Chen, Chong Chi Chiu, Jieh Neng Wang, Ching Hsia Hung, Jhi Joung Wang

研究成果: Article

7 引文 (Scopus)

摘要

Background The aim of the study was to compare the proposed spinal anesthetic effect of ifenprodil, an alpha receptor antagonist, with that of the long-acting local anesthetic bupivacaine. Methods After intrathecally injecting the rats with five different doses of each drug, the dose-response curves of ifenprodil and bupivacaine were constructed to obtain the 50% effective dose (ED50). The spinal blockades of motor function and nociception of ifenprodil were compared with that of bupivacaine. Results We showed that either ifenprodil or bupivacaine produced spinal blockades of motor function and nociception dose-dependently. On the ED50 basis, the potency of ifenprodil (0.42(0.38-0.46) μmol; 0.40(0.36-0.44) μmol) was equal (p > 0.05) to that of bupivacaine (0.38(0.36-0.40) μmol; 0.35(0.32-0.38) μmol) in motor function and nociception, respectively. At the equianesthetic doses (ED25, ED50, and ED75), duration produced by ifenprodil was greater than that produced by bupivacaine in motor function and nociception (p < 0.05 for the differences). Furthermore, both ifenprodil and bupivacaine showed longer duration of sensory blockade than that of motor blockade (p < 0.05 for the differences). Conclusions The resulting data demonstrated that ifenprodil produces a dose-dependent local anesthetic effect in spinal anesthesia. Ifenprodil shows a more sensory-selective duration of action over motor block, whereas the duration of anesthesia is significantly longer with ifenprodil than with bupivacaine.

原文English
頁(從 - 到)357-362
頁數6
期刊Pharmacological Reports
68
發行號2
DOIs
出版狀態Published - 2016 四月 1

指紋

Nociception
Bupivacaine
Local Anesthetics
Anesthetics
ifenprodil
Spinal Anesthesia
Anesthesia

All Science Journal Classification (ASJC) codes

  • Pharmacology

引用此文

Chen, Yu Wen ; Chiu, Chong Chi ; Wang, Jieh Neng ; Hung, Ching Hsia ; Wang, Jhi Joung. / Ifenprodil for prolonged spinal blockades of motor function and nociception in rats. 於: Pharmacological Reports. 2016 ; 卷 68, 編號 2. 頁 357-362.
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Ifenprodil for prolonged spinal blockades of motor function and nociception in rats. / Chen, Yu Wen; Chiu, Chong Chi; Wang, Jieh Neng; Hung, Ching Hsia; Wang, Jhi Joung.

於: Pharmacological Reports, 卷 68, 編號 2, 01.04.2016, p. 357-362.

研究成果: Article

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AU - Hung, Ching Hsia

AU - Wang, Jhi Joung

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AB - Background The aim of the study was to compare the proposed spinal anesthetic effect of ifenprodil, an alpha receptor antagonist, with that of the long-acting local anesthetic bupivacaine. Methods After intrathecally injecting the rats with five different doses of each drug, the dose-response curves of ifenprodil and bupivacaine were constructed to obtain the 50% effective dose (ED50). The spinal blockades of motor function and nociception of ifenprodil were compared with that of bupivacaine. Results We showed that either ifenprodil or bupivacaine produced spinal blockades of motor function and nociception dose-dependently. On the ED50 basis, the potency of ifenprodil (0.42(0.38-0.46) μmol; 0.40(0.36-0.44) μmol) was equal (p > 0.05) to that of bupivacaine (0.38(0.36-0.40) μmol; 0.35(0.32-0.38) μmol) in motor function and nociception, respectively. At the equianesthetic doses (ED25, ED50, and ED75), duration produced by ifenprodil was greater than that produced by bupivacaine in motor function and nociception (p < 0.05 for the differences). Furthermore, both ifenprodil and bupivacaine showed longer duration of sensory blockade than that of motor blockade (p < 0.05 for the differences). Conclusions The resulting data demonstrated that ifenprodil produces a dose-dependent local anesthetic effect in spinal anesthesia. Ifenprodil shows a more sensory-selective duration of action over motor block, whereas the duration of anesthesia is significantly longer with ifenprodil than with bupivacaine.

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