IL-19 induced Th2 cytokines and was up-regulated in asthma patients

Sheng Chin Liao, Yung Chih Cheng, Yo Ching Wang, Chiung Wen Wang, San Ming Yang, Chun Keung Yu, Chi Chang Shieh, Kuo Chen Cheng, Meng Feng Lee, Shyh Ren Chiang, Jiunn Min Shieh, Ming Shi Chang

研究成果: Article同行評審

138 引文 斯高帕斯(Scopus)

摘要

IL-19 belongs to the IL-10 family, which includes IL-10, IL-19, IL-20, IL-22, melanoma differentiation-associated gene-7 (IL-24), and AK155 (IL-26). IL-10 has been shown to inhibit allergen-induced airway hyperreactivity and inflammation. To determine whether IL-19 was also associated with asthma, we used ELISA to analyze the serum level of IL-19 in patients with asthma and found that their serum IL-19 levels were twice those of healthy controls. Patients with a high level of IL-19 also had high levels of IL-4 and IL-13. In a dust mite-induced murine model of asthma, we found that IL-19 level in asthmatic BALB/cJ mice was also twice that of healthy control mice. IL-19 transcript was also induced in the lungs of asthmatic mice. Electroporation i.m. of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13. However, IL-19 up-regulated IL-13 in asthmatic mice. In vitro, IL-19 induced IL-4, IL-5, IL-10, and IL-13 production by activated T cells. Activation of T cells was required for induction of IL-13 because IL-19 did not induce IL-13 production on nonstimulated T cells. Taken together, these results demonstrated that IL-19 up-regulates Th2 cytokines on activated T cells and might play an important role in the pathogenesis of asthma.

原文English
頁(從 - 到)6712-6718
頁數7
期刊Journal of Immunology
173
發行號11
DOIs
出版狀態Published - 2004 十二月 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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