IL-24 inhibits the growth of hepatoma cells in vivo

Wei Yu Chen, Y. T. Cheng, H. Y. Lei, C. P. Chang, C. W. Wang, Ming Shi Chang

研究成果: Article同行評審

43 引文 斯高帕斯(Scopus)


The interleukin (IL)-24/melanoma differentiation associated gene-7 (mda-7) is a member of the IL-10 cytokine family. Introduction of the IL-24 gene into a variety of cancer cells suppresses their growth. It has not been shown, however, whether IL-24 can suppress the growth of hepatoma cells. The purpose of this study was to determine whether the mouse (m)IL-24 gene would suppress hepatoma cells in vivo after being delivered via intramuscular electroporation. After mice were given a subcutaneous dorsal injection of ML-1 hepatoma cells, the mIL-24 gene was delivered and suppressed tumor growth. On day 140, 60% of the mIL-24-treated mice (n=10) and 0% (n=10) of the untreated control mice had survived. We also generated a mouse-hepatoma model by injecting ML-1 cells into the spleen, which resulted in tumor metastasis in the liver. Intramuscular electroporation of mIL-24 also inhibited hepatoma-cell growth in the liver. On day 50, 90% of the experimental mice (n=10) and 40% (n=10) of the control mice had survived. Liver tumors in surviving experimental mice were 50% smaller than those in control mice. IL-24 also inhibited tumor vascularization. These results suggest that IL-24 has potential therapeutic value for hepatoma.

頁(從 - 到)493-499
期刊Genes and Immunity
出版狀態Published - 2005 9月

All Science Journal Classification (ASJC) codes

  • 免疫學
  • 遺傳學
  • 遺傳學(臨床)


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