Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer

Wu Wei Lai, Fen Fen Chen, Ming Ho Wu, Nan Haw Chow, Wu Chou Su, Mi Chia Ma, Pei Fang Su, Helen Chen, Mu Yen Lin, Yau Lin Tseng

研究成果: Article

35 引文 斯高帕斯(Scopus)

摘要

Background. To elucidate the relationship between the expression of epidermal growth factor receptor family members (ErbB-1, neu/ErbB-2, ErbB-3, and ErbB-4) and tumor recurrence. Methods. We used immunohistochemistry to examine the expression of four epidermal growth factor receptor family members in 73 patients with stage I non-small cell lung cancer. Results. Using Cox univariate analysis, we determined that angiolymphatic tumor emboli and non-well-differentiated tumor cells were two significant conventional pathologic predictors of tumor recurrence, and that ErbB-1 and ErbB-3 were also significant predictors. Co-expression of ErbB-1+, -3+, or expression of three or more epidermal growth factor receptor family members had a significant effect on lung cancer recurrence. A stepwise multivariate Cox proportional hazards regression analysis provided a predictive model for tumor recurrence. Conclusions. The present study shows that in patients with a non-well-differentiated tumor, overexpression of ErbB-3 is a useful marker for predicting tumor recurrence. The present study also confirmed that ErbB-1 expression increased in proportion to the loss of tumor differentiation. The correlation between ErbB-3 and distant metastasis was good.

原文English
頁(從 - 到)1868-1876
頁數9
期刊Annals of Thoracic Surgery
72
發行號6
DOIs
出版狀態Published - 2001 十二月 1

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

指紋 深入研究「Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer」主題。共同形成了獨特的指紋。

  • 引用此