Immunohistochemical analysis of nm23-H1 in stage I non-small cell lung cancer: A useful marker in prediction of metastases

Wu Wei Lai, Ming Ho Wu, Jing Jou Yan, Feng Feng Chen

研究成果: Article同行評審

16 引文 斯高帕斯(Scopus)

摘要

Background. About 30% to 40% of patients with pathologic stage I non-small cell lung cancer die within 5 years after complete resection. The identification of subgroups with high risk of recurrence is important. The level of nm23-H1/nucleoside diphosphate kinase expression has been reported to correlate inversely with the metastatic potential of some tumors. Methods. We examined immunohistochemically the expression of nm23-H1 in 32 stage I non-small cell lung cancers to determine its value in predicting the outcome of the operation. Results. Twelve (37.5%) recurrences and ten deaths occurred in this series. There were eight (25%) distant and four (12.5%) locoregional recurrences. Of the 32 pathologic stage I non-small cell lung cancers, 10 (31.3%) were positive for nm23-H1 gene product. None of the patients with a higher nm23-H1 protein level had detectable distant metastases at the end of this study (χ2 test, p < 0.05). The median follow-up time to date is only 35 months (range, 18 to 83 months), and so far no significant difference in overall survival rate has been observed between the groups with high and low nm23-H1 protein levels. Conclusions. The level of nm23-H1 protein is more useful than the T status or histologic type for the prediction of distant metastases, whereby cases may be selected for postoperative adjuvant chemotherapy.

原文English
頁(從 - 到)1500-1504
頁數5
期刊Annals of Thoracic Surgery
62
發行號5
DOIs
出版狀態Published - 1996 11月

All Science Journal Classification (ASJC) codes

  • 手術
  • 肺和呼吸系統醫學
  • 心臟病學與心血管醫學

指紋

深入研究「Immunohistochemical analysis of nm23-H1 in stage I non-small cell lung cancer: A useful marker in prediction of metastases」主題。共同形成了獨特的指紋。

引用此