Immunomodulation and mechanisms of fucoidan from Cladosiphon okamuranus ameliorates atopic dermatitis symptoms

Bo Rui Chen, Kung Ting Hsu, Wei Hsuan Hsu, Bao Hong Lee, Tsung Lin Li, Yi Lin Chan, Chang Jer Wu

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

Atopic dermatitis (AD) is a long-term allergic skin disorder that occurs most frequently in children. Currently, the common treatment of AD is corticosteroids; however, the drugs cause serious side effects. Therefore, there are many patients who seek complementary and alternative treatments such as healthy food. We report that fucoidan from Cladosiphon okamuranus (COP) exhibit exceptional immuno-modulatory effects significantly improving atopic dermatitis (AD) at both in vitro and in vivo levels: First, we performed the P815 cell degranulation assay, of which the results revealed that COP possesses anti-degranulation activity suggesting COP is very conducive to relieving allergic reactions of AD. Next, we performed the animal model examination, of which AD was significantly improved, suggesting COP can focally and globally modulate the immune systems of animals. The systemic improvements were manifested clearly by decreased epidermal hyperplasia, reduced infiltration of eosinophils, and decreased expression of AD-associated cytokines. Notably, COP reduced epidermal hyperplasia by downregulating the expression of IL-22. COP displayed therapeutic effects, which is comparable to corticosteroids but lack corticosteroid side effects, such as weight loss in our animal study. COP is multitudinous immunomodulatory abilities to serve as a healthy food supplement at the current stage, not least beneficial to atopic dermatitis.

原文English
頁(從 - 到)537-543
頁數7
期刊International Journal of Biological Macromolecules
189
DOIs
出版狀態Published - 2021 10月 31

All Science Journal Classification (ASJC) codes

  • 結構生物學
  • 生物化學
  • 分子生物學
  • 經濟學與計量經濟學
  • 一般能源

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