@article{735e22bc4a3342f28a8df0cd1afc0c7c,
title = "Impact of revised CLSI breakpoints for susceptibility to third-generation cephalosporins and carbapenems among Enterobacteriaceae isolates in the Asia-Pacific region: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2002-2010",
abstract = "This study examined the rates of susceptibility to third-generation cephalosporins and carbapenems among Enterobacteriaceae isolates that had been obtained from patients with intraabdominal infections in the Asia-Pacific region as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). Susceptibility profiles obtained using 2009 Clinical and Laboratory Standards Institute (CLSI) breakpoints were compared with those obtained using the 2011 CLSI breakpoints. From 2002 to 2010, Escherichia coli and Klebsiella pneumoniae together accounted for more than 60 of the 13714 Enterobacteriaceae isolates analyzed during the study period. Extended-spectrum β-lactamase (ESBL) producers comprised 28.2 of E. coli isolates and 22.1 of K. pneumoniae isolates in the Asia-Pacific region, with China (55.6 and 33.7, respectively) and Thailand (43.1 and 40.7, respectively) having the highest proportions of ESBL producers. Based on the 2011 CLSI criteria, 77.2 of the Enterobacteriaceae isolates, 40.4 of ESBL-producing E. coli, and 25.2 of ESBL-producing K. pneumoniae isolates were susceptible to ceftazidime. Carbapenems showed in vitro activity against >90 of Enterobacteriaceae isolates in all participating countries, except for ertapenem in South Korea (susceptibility rate 82.2). Marked differences (>5) in susceptibility of ESBL-producing E. coli and K. pneumoniae isolates to carbapenems were noted between the profiles obtained using the 2009 CLSI criteria and those using the 2011 CLSI criteria. Continuous monitoring of antimicrobial resistance is necessary in the Asia-Pacific region.",
author = "Huang, {Chi Chang} and Chen, {Yao Shen} and Toh, {Han Siong} and Lee, {Yu Lin} and Liu, {Yuag Meng} and Ho, {Cheng Mao} and Lu, {Po Liang} and Liu, {Chun Eng} and Chen, {Yen Hsu} and Wang, {Jen Hsien} and Tang, {Hung Jen} and Yu, {Kwok Woon} and Liu, {Yung Ching} and Chuang, {Yin Ching} and Yingchun Xu and Yuxing Ni and Ko, {Wen Chien} and Hsueh, {Po Ren}",
note = "Funding Information: We thank all the investigators in the Asia-Pacific region for their participation in the SMART program. The Asia-Pacific SMART team included: Tony Korman, Monash Medical Center, Australia; David Paterson, Royal Brisbane Hospital, Australia; Geoffrey Coombs, Royal Perth Hospital, Australia; Lee Thomas, Westmead Hospital, Australia; Bi Jie Hu, Fu Dan University Affiliated Zhong Shan Hospital, Shanghai, China; Ziyong Sun, Tongji Medical School of Mid-China, Wuhan, China; Wenxiang Huang, Chongqing Medical University Affiliate No. 1 Hospital, Chongqing, China; Yingchun Xu, Peking Union Medical College Hospital, Beijing, China; Yu Xing Ni, Shanghai Rui Jin Hospital, Shanghai, China; Yun Song Yu, Zhe Jiang University College of Medicine Affiliate, Hangzhou, China; Kang Liao, 1st Affiliated Hospital of Sun Yat-Sen University, China; Xianju Feng, 1st Affiliated Hospital of Zhengzhou University, China; Chu Yun Zhuo, First Hospital of China Medical University, China; Dingxia Shen, General Hospital of PLA, China; Zhidong Hu, General Hospital of Tianjin Medical University, China; Yong Wang, Provincial Hospital Shandong University, China; Huang Xun, Xiangya Hospital of Central South University, China; Thomas Kin Wah Ling, Prince of Wales Hospital, Hong Kong SAR, Hong Kong; Raymond Leung, Queen Mary Hospital, Hong Kong; Bhaskar N. Chaudhuri, AMRI Hospitals, Kolkata, India; Camilla Rodrigues, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, India; Ranganathan Iyer, Global Hospitals, Hyderabad, India; Sangeeta Joshi, Manipal Hospital, Bangalore, India; T.N. Dhole, SCPGI, Lucknow, India; Uma Sekar, Sri Ramachandra Medical College, Chennai, Porur, India; V. Balaji, Christian Medical College, Vellore, India; Datin Ganeswrie, Hospital Sultanah Aminah, Johor Bahru, Malaysia; Muhammand Nazri, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; Myrna Mendoza, Philippines General Hospital, Manila, Philippines; Evelina Lagamayo, St. Luke's Medical Center, Philippines; Prabha Unny Krishnan, Tan Tock Seng Hospital, Singapore, Singapore; Thean Yen Tan, Changi General Hospital, Singapore, Singapore; Wee-Gyo Lee, Ajou University Hospital, Suwon, South Korea; Chun-Eng Liu, Changhua Christian Hospital, Changhua, Taiwan; Jen-Hsien Wang, China Medical College-Hospital, Taichung, Taiwan; Kenneth Yin-Ching Chuang, Chi-Mei Medical Center, Tainan, Taiwan; Kwok-Woon Yu, Taipei Veterans General Hospital, Taipei, Taiwan; Po-Liang Lu, Chung-Ho Memorial Hospital, Kaohsiung, Taiwan; Po-Ren Hsueh, National Taiwan University Hospital, Taipei, Taiwan; Yao-Shen Chen, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Wen-Chien Ko, National Cheng Kung University Hospital, Tainan, Taiwan; Sineenart Kalnauwakul, Songklanakarin Hospital, Songkla, Thailand; Pattarchai Kirathisin, Siriraj Hospital, Thailand; Tran Thi Lan Phuong, Benh Vien Viet Duc, Hanoi, Vietnam; Nguyen Tran My Phoung, Bihn Dan Hospital, Vietnam; Tran Thi Than Nga, Cho Ray Hospital, Vietnam; Tim Blackmore, Wellington Hospital, Wellington, New Zealand; Sally Roberts, Auckland City Hospital, Auckland, New Zealand; Susan Taylor, Middlemore Hospital at Counties Manukau District, Otahuhu, New Zealand; Dragana Drinkovic, North Shore Hospital, New Zealand. ",
year = "2012",
month = jun,
doi = "10.1016/S0924-8579(12)70003-1",
language = "English",
volume = "40",
pages = "S4--S10",
journal = "International journal of antimicrobial agents",
issn = "0924-8579",
publisher = "Elsevier",
number = "SUPPL. 1",
}