Impaired callosal motor fiber integrity and upper extremity motor impairment are associated with stroke lesion location

Lin Chia-Koh, Fang Pei-Tang, Hsiu I. Chen, Chin Yung-Hsu, Lin Ching-Hsieh, Wen Yih Isaac Tseng

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background. Damage to the callosal motor fibers (CMFs) may affect motor recovery in patients with stroke. However, whether the severity of CMF impairment varies with lesion locations remains unclear. Objective. To investigate (1) whether CMF impairment occurs after stroke and whether the impairment varies with lesion locations and (2) the associations of CMF impairment and upper extremity (UE) motor impairment. Methods. Twenty-nine patients with lesions involving the corticospinal tract (CST) were categorized into 2 groups: lesions involving the CMFs (CMF group, n = 15), and lesions not involving the CMFs (non-CMF group, n = 14). Thirteen healthy adults served as the control group. Tract integrity, assessed by the mean generalized fractional anisotropy (mGFA) using diffusion spectrum imaging, of the CMFs and the CST above the internal capsule (CST ABOVE ) of the ipsilesional hemisphere were compared. Results. After accounting for the effect of lesion load on the CST, the CMF group exhibited a significantly lower mGFA of the CMFs than did the control and non- CMF groups (post hoc P =.005 and.001, respectively). No significant difference was observed between the non-CMF and control groups (post hoc P =.999). The CST and CMF impairment accounted for 56% of the variance of UE motor impairment in the CMF group (P =.007), whereas no significant association was observed in the non-CMF group (P =.570). Conclusions. CMF impairment after stroke depends on lesion locations and CMF integrity has an incremental contribution to the severity of UE motor impairment in the CMF group.

原文English
頁(從 - 到)602-612
頁數11
期刊Neurorehabilitation and Neural Repair
32
發行號6-7
DOIs
出版狀態Published - 2018 六月 1

All Science Journal Classification (ASJC) codes

  • 復健
  • 神經內科
  • 神經病學(臨床)

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