TY - GEN
T1 - Improve blood compatibility of bioresorbable magnesium stents coated with functionalized anti-CD34 antibody and heparin-collagen multiplayers
AU - Lai, Yi Ping
AU - Kan, Chung Dann
N1 - Funding Information:
Research supported by MOST 104-2314-B-006-090, MOST 102-2314-B-006-030-MY3 Foundation. Chung-Dann Kan, MD, PhD is the corresponding author and with the Division of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan (phone:+886-6-2353535#5231; fax:06-2766676; e-mail: kcd56@mail.ncku.edu.tw; kcd0586@gmail.com).
Funding Information:
This study was also supported by funding from the medical science and technology research grant at National Cheng Kung University Hospital under contract number nckuh-10506021. This work was also supported in part by the Ministry of Science and Technology, Taiwan, under contract numbers NSC102-2314-B-006-030-MY3.
Publisher Copyright:
© 2017 IEEE.
PY - 2017/9/13
Y1 - 2017/9/13
N2 - Instentrestenosis and late stent thrombosis continue to be the greatest limitations of drug-eluting stents. In this study, an anti-CD34 antibody functionalized multilayer of heparin/collagen type I is developed by layer-by-layer assemble to enhance biocompatibility and recruit endothelial progenitor cells. The SEM results demonstrate that (Hep/Col)5-coated samples have a rougher surface compared to (Hep/Col)2-coated samples and untreated samples. The EDX and FTIR results both confirmed the presence of heparin and collagen onto the modified samples. The immunofluorescence staining outcomes demonstrated that anti-CD34 antibody has successfully immobilized onto modified Mg discs.
AB - Instentrestenosis and late stent thrombosis continue to be the greatest limitations of drug-eluting stents. In this study, an anti-CD34 antibody functionalized multilayer of heparin/collagen type I is developed by layer-by-layer assemble to enhance biocompatibility and recruit endothelial progenitor cells. The SEM results demonstrate that (Hep/Col)5-coated samples have a rougher surface compared to (Hep/Col)2-coated samples and untreated samples. The EDX and FTIR results both confirmed the presence of heparin and collagen onto the modified samples. The immunofluorescence staining outcomes demonstrated that anti-CD34 antibody has successfully immobilized onto modified Mg discs.
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U2 - 10.1109/EMBC.2017.8037260
DO - 10.1109/EMBC.2017.8037260
M3 - Conference contribution
C2 - 29060303
AN - SCOPUS:85032173622
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 2068
EP - 2071
BT - 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
Y2 - 11 July 2017 through 15 July 2017
ER -