Improved therapeutic efficacy via magnetite nanoconjugates derived synchronization of hyperthermochemotherapy

研究成果: Conference contribution

摘要

A novel nanoconjugate enabled synchronization of localized hyperthermia and drug release was presented. The hyperthermia was induced by the radiofrequency (RF) at 1.3MHz to trigger the release of 5-fluouracil (5-FU) anti-cancer drugs from magnetite nanocrystals core by breaking their hydrogen bond with the polynucleotide polymer carrier. The anti-Human Epidermal Growth Factor Receptor 2 (anti-HER2) antibody was end-modified on the polyethylene glycol to achieve cancer cell specific targeting and biological stealth. The 22 nm-sized magnetites displayed high saturation magnetization (94 emu/g) comparable to bulk magnetite (92 emu/g). The local regional heat triggers synchronized drug release and physical thermal damage of the cancer cells and significantly improved the anti-cancer efficacy in both in vitro and in vivo models than hyperthermia or chemotherapy alone as evidenced by cell viability assays and pathological examines. Complete remission of the disease in vivo was achieved through radiofrequency synchronization of hyperthermia and chemotherapy after intravenous injection of the nanoconjugates.

原文English
主出版物標題2012 12th IEEE International Conference on Nanotechnology, NANO 2012
DOIs
出版狀態Published - 2012 十一月 22
事件2012 12th IEEE International Conference on Nanotechnology, NANO 2012 - Birmingham, United Kingdom
持續時間: 2012 八月 202012 八月 23

出版系列

名字Proceedings of the IEEE Conference on Nanotechnology
ISSN(列印)1944-9399
ISSN(電子)1944-9380

Other

Other2012 12th IEEE International Conference on Nanotechnology, NANO 2012
國家/地區United Kingdom
城市Birmingham
期間12-08-2012-08-23

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 電氣與電子工程
  • 材料化學
  • 凝聚態物理學

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