Improving the surface biocompatibility with the use of mixed zwitterionic self-assembled monolayers prepared by a proper solvent

Ching Hsiung Shen, Jui Che Lin

研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)

摘要

In this study, the mixed self-assembled monolayers (SAMs) containing the mixture of long-chain alkanethiol, SH(CH2)11NH2 and SH(CH2)10SO3H, was prepared as a model surface to examine the interaction between the biological environment and artificial surface. The 10% (v/v) NH4OH ethanolic solution and DMSO were chosen as the solvents for the preparation of these mixed SAMs and the "solvent effect" was discussed. X-ray photoelectron spectroscopy (XPS) has indicated that -SO3H/-NH2 mixed SAMs formed from 10% (v/v) NH4OH ethanolic solution were surface "-SO3H poor", while a nearly equivalent amount of surface -SO3H functionality was presented on the mixed SAMs formed from DMSO. This has resulted from the different solvation capability between solvent molecules and the alkanethiol. Such solvent effects were also reflected in various surface properties such as surface wettability and surface zeta potential. The mixed SAMs formed from DMSO were more surface hydrophilic and less negatively surface charged than from 10% (v/v) NH4OH ethanolic solution. In addition, these mixed SAMs formed from DMSO exhibited the least amount of protein adsorbed as well as a better platelet compatibility than its counterpart from 10% (v/v) NH4OH ethanolic solution. These findings indicated that choosing a proper solvent for mixed zwitterionic SAM can greatly affect its surface properties and biocompatibility, such as to form a surface with near neutrality for reducing protein adsorption and subsequent platelet adhesion and activation.

原文English
頁(從 - 到)7091-7098
頁數8
期刊Langmuir
27
發行號11
DOIs
出版狀態Published - 2011 六月 7

All Science Journal Classification (ASJC) codes

  • 材料科學(全部)
  • 凝聚態物理學
  • 表面和介面
  • 光譜
  • 電化學

指紋

深入研究「Improving the surface biocompatibility with the use of mixed zwitterionic self-assembled monolayers prepared by a proper solvent」主題。共同形成了獨特的指紋。

引用此