In situ circular compression and doppler optical coherence tomography studies on effects of diabetic mellitus on vesa nervonum of sciatic nerve

Eric Chia, Chou Chin Lin, Chung Yi Sue, Ming Shaung Ju

研究成果: Conference contribution

摘要

Diabetes mellitus is one of the most common diseases in the world and can causemany types of neuropathies, and even mortality. It is therefore important to understand how diabetes mellitus alters the mechanical properties of nerve tissues and their blood vessels. In this study, in situ compression- and-hold circular compression tests were applied to the sciatic nerves of both diabetic rats and normal rats. Doppler optical coherence tomography (Doppler OCT) was then utilized to monitor the configuration of the arterioles in two groups of rats. The force data acquired in the compression tests were fitted by using Fung’s quasi-linear viscoelastic model (QLV) to determine the viscoelasticity of the nerves. The results show that the nerves in the diabetic group had a longer relaxation time than those in the normal group. Consequently, the Doppler OCT observations reveal that in contrast to the normal arterioles, the diabetic arterioles did not dilate in the relaxation phase. The results of the force data integrated with the corresponding arteriole dilatation images may explain why the diabetic patients are more prone to carpal tunnel syndrome. The results may facilitate developing new approaches for treating diabetic neuropathy and for nerve repair and regeneration.

原文English
主出版物標題1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
編輯Fong-Chin Su, Ming-Long Yeh, Shyh-Hau Wang
發行者Springer Verlag
頁面42-45
頁數4
ISBN(電子)9783319122618
DOIs
出版狀態Published - 2015
事件1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan
持續時間: 2014 十月 92014 十月 12

出版系列

名字IFMBE Proceedings
47
ISSN(列印)1680-0737
ISSN(電子)1433-9277

Other

Other1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
國家Taiwan
城市Tainan
期間14-10-0914-10-12

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

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