TY - JOUR
T1 - In situ photoimmunotherapy is ineffective in treating deeply invasive squamous cell carcinoma
AU - Wong, Tak Wah
AU - Tsao, Stephanie
AU - Lee, Julia Yu Yun
N1 - Funding Information:
This work was supported by the Taiwan Science Council grants (grant nos. NSC992627E033001 and NSC1002627E033001 ) and the Taiwan Department of Health grant to establish centers of excellence for cancer research in Taiwan (grant no. DOH101TDC111003 to T.-W.W.). The authors also thank Dr Michael W. Hughes for his critical review of this article.
PY - 2014/6
Y1 - 2014/6
N2 - In situ photoimmunotherapy (ISPI) can be a treatment option for selected cutaneous malignancies in patients who are not surgical candidates. We herein report the case of a large, ulcerating poorly differentiated squamous cell carcinoma (SCC) affecting the foot of an elderly woman with chronic arsenicosis. The tumor failed radiotherapy, intralesional methotrexate, and 5-aminolevulinic acid photodynamic therapy (PDT). Because the patient was reluctant to undergo amputation, the recurrent tumor was treated with ISPI using topical imiquimod application followed by PDT. Despite some initial improvement in the superficial part of the tumor, tumor invasion to the underlying bone was detected. This case illustrates the lack of efficacy of ISIP in treating a high-risk invasive SCC.
AB - In situ photoimmunotherapy (ISPI) can be a treatment option for selected cutaneous malignancies in patients who are not surgical candidates. We herein report the case of a large, ulcerating poorly differentiated squamous cell carcinoma (SCC) affecting the foot of an elderly woman with chronic arsenicosis. The tumor failed radiotherapy, intralesional methotrexate, and 5-aminolevulinic acid photodynamic therapy (PDT). Because the patient was reluctant to undergo amputation, the recurrent tumor was treated with ISPI using topical imiquimod application followed by PDT. Despite some initial improvement in the superficial part of the tumor, tumor invasion to the underlying bone was detected. This case illustrates the lack of efficacy of ISIP in treating a high-risk invasive SCC.
UR - https://www.scopus.com/pages/publications/84901242234
UR - https://www.scopus.com/pages/publications/84901242234#tab=citedBy
U2 - 10.1016/j.dsi.2013.05.006
DO - 10.1016/j.dsi.2013.05.006
M3 - Article
AN - SCOPUS:84901242234
SN - 1027-8117
VL - 32
SP - 90
EP - 92
JO - Dermatologica Sinica
JF - Dermatologica Sinica
IS - 2
ER -
SDG 3 良好的健康和福祉