In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila

W. C. Ko; H. C. Lee; Y. C. Chuang; S. H. Ten; C. Y. Su; J. J. Wu

doi:10.1128/AAC.45.4.1281-1283.2001

In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila

W. C. Ko, H. C. Lee, Y. C. Chuang, S. H. Ten, C. Y. Su, J. J. Wu

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摘要

The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.

原文	English
頁（從 - 到）	1281-1283
頁數	3
期刊	Antimicrobial agents and chemotherapy
卷	45
發行號	4
DOIs	https://doi.org/10.1128/AAC.45.4.1281-1283.2001
出版狀態	Published - 2001

All Science Journal Classification (ASJC) codes

藥理
藥學（醫學）
傳染性疾病

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10.1128/AAC.45.4.1281-1283.2001

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AU - Su, C. Y.

AU - Wu, J. J.

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AB - The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.

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ER -

In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila

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