In Vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus

Hung Jen Tang, Chi Chung Chen, Kuo Chen Cheng, Kuan Ying Wu, Yi Chung Lin, Chun Cheng Zhang, Tzu Chieh Weng, Wen Liang Yu, Yu Hsin Chiu, Han Siong Toh, Shyh Ren Chiang, Bo An Su, Wen Chien Ko, Yin Ching Chuang

研究成果: Article

38 引文 斯高帕斯(Scopus)

摘要

To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline alone or in combination with rifampin against biofilm-embedded MRSA were measured. The rifampin-resistant mutation frequencies were evaluated. Of the rifampin-based combinations, rifampin enhances the antibacterial activities of and even synergizes with fusidic acid, tigecycline, and, to a lesser extent, linezolid, fosfomycin, and minocycline against biofilm-embedded MRSA. Such combinations with weaker rifampin resistance induction activities may provide a therapeutic advantage in MRSA biofilm-related infections.

原文English
頁(從 - 到)5717-5720
頁數4
期刊Antimicrobial agents and chemotherapy
57
發行號11
DOIs
出版狀態Published - 2013 十一月

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Tang, H. J., Chen, C. C., Cheng, K. C., Wu, K. Y., Lin, Y. C., Zhang, C. C., Weng, T. C., Yu, W. L., Chiu, Y. H., Toh, H. S., Chiang, S. R., Su, B. A., Ko, W. C., & Chuang, Y. C. (2013). In Vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 57(11), 5717-5720. https://doi.org/10.1128/AAC.01236-13