In vivo monitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques

Cheng Kuan Su, Yuh Chang Sun, Shun Fen Tzeng, Chung Shi Yang, Chin Yen Wang, Mo Hsiung Yang

研究成果: Article同行評審

20 引文 斯高帕斯(Scopus)

摘要

The roles of metal ions to sustain normal function and to cause dysfunction of neurological systems have been confirmed by various studies. However, because of the lack of adequate analytical method to monitor the transfer kinetics of metal ions in the brain of a living animal, research on the physiopathological roles of metal ions in the CNS remains in its early stages and more analytical efforts are still needed. To explicitly model the possible links between metal ions and physiopathological alterations, it is essential to develop in vivo monitoring techniques that can bridge the gap between metalloneurochemistry and neurophysiopathology. Although inductively coupled plasma mass spectrometry (ICP-MS) is a very powerful technique for multiple trace element analyses, when dealing with chemically complex microdialysis samples, the detection capability is largely limited by instrumental sensitivity, selectivity, and contamination that arise from the experimental procedure. As a result, in recent years several high efficient and clean on-line sample pretreatment systems have been developed and combined with microdialysis and ICP-MS for the continuous and in vivo determination of the concentrationtime profiles of metal ions in the extracellular space of rat brain. This article reviews the research relevant to the development of analytical techniques for the in vivo determination of dynamic variation in the concentration levels of metal ions in a living animal.

原文English
頁(從 - 到)392-424
頁數33
期刊Mass Spectrometry Reviews
29
發行號3
DOIs
出版狀態Published - 2010 5月

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 凝聚態物理學
  • 一般生物化學,遺傳學和分子生物學
  • 光譜

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