In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse

Yuan Li Huang, Sew Fen Leu, Bi Ching Liu, Chia Chin Sheu, Bu-Miin Huang

研究成果: Article

33 引文 (Scopus)

摘要

Cordyceps sinensis (CS), an Ascomycetes fungus parasitic to Lepidoptera larvae, has been traditionally used as nutritious food for the enhancement on sexual performance and the restitution of impairment in sexual function in Chinese society. We have previously demonstrated the stimulatory effect of CS and its fractions on steroidogenesis both on primary mouse Leydig cells and MA-10 mouse Leydig tumor cells. In the present studies, we determined the in vivo effects of CS and its fractions on steroidogenesis in mouse. Different concentrations of CS and CS fractions (0.02 and 0.2 mg/g body weight) were fed to immature or mature mice from 1 to 7 days. The plasma levels of testosterone were evaluated by radioimmunoassay. The weights of reproductive organs were also determined. Results illustrated that CS significantly induced plasma testosterone levels both in immature and mature mice in 3 and/or 7 days treatment (p < 0.05). F2 and F3 at 0.02 and/or 0.2 mg/g body weight for different feeding duration could also significantly stimulated plasma testosterone levels both in immature and mature mice (p < 0.05). In general, CS, F2 and F3 didn't have considerable effect on the weights of reproductive organs. Taken together, these studies illustrate that CS and its fractions significantly stimulated in vivo mouse testosterone production.

原文English
頁(從 - 到)1051-1062
頁數12
期刊Life Sciences
75
發行號9
DOIs
出版狀態Published - 2004 七月 16

指紋

Cordyceps
Mycelium
Testosterone
Plasmas
Organ Size
Fungi
Tumors
Cells
Body Weight
Leydig Cell Tumor
Ascomycota
Lepidoptera
Leydig Cells
Radioimmunoassay
Larva
Food

All Science Journal Classification (ASJC) codes

  • Pharmacology

引用此文

Huang, Yuan Li ; Leu, Sew Fen ; Liu, Bi Ching ; Sheu, Chia Chin ; Huang, Bu-Miin. / In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse. 於: Life Sciences. 2004 ; 卷 75, 編號 9. 頁 1051-1062.
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In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse. / Huang, Yuan Li; Leu, Sew Fen; Liu, Bi Ching; Sheu, Chia Chin; Huang, Bu-Miin.

於: Life Sciences, 卷 75, 編號 9, 16.07.2004, p. 1051-1062.

研究成果: Article

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