Increased arterial stiffness in subjects with impaired glucose tolerance and newly diagnosed diabetes but not isolated impaired fasting glucose

Chung-Hao Li, Jin-Shang Wu, Yi-Ching Yang, Chi Chen Shih, Feng-Hwa Lu, Chih-Jen Chang

研究成果: Article同行評審

67 引文 斯高帕斯(Scopus)

摘要

Context: Studies have shown that diabetes mellitus increased brachial-ankle pulse-wave velocity (baPWV), but the impact of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) remains controversial. Objective: Our objective was to investigate the impact of the different glycemic states on baPWV in a relatively healthy Chinese population. Design, Setting, and Patients: We enrolled 4938 subjects in the health examination center of the National Cheng Kung University Hospital from October 2006 to August 2009 after excluding those who were under medications for diabetes, hypertension, or hyperlipidemia or had a history of cardiovascular disease. Main Outcome Measures: The baPWV values to assess arterial stiffness were calculated as the distance traveled by the pulse wave divided by the time taken to travel the distance. The participants were classified into normal glucose tolerance (NGT; n = 3777), isolated IFG (n = 221), IGT (n = 726), and newly diagnosed diabetes (NDD; n = 214) groups. Results: The mean values of baPWV were 1284.9 ± 205.2, 1379.6 ± 226.8, 1408.1 ± 251.7, and 1500.8 ± 282.5 cm/sec in NGT, isolated IFG, IGT, and NDD groups, respectively. The isolated IFG, IGT, and NDD groups had a higher baPWV value as compared with the NGT group. In a multiple linear regression test, both IGT and NDD groups, but not the isolated IFG group, had significantly higher baPWV values after adjustment for age, sex, body mass index, waist to hip ratio, smoking, alcohol consumption, habitual exercise, systolic blood pressure, and lipid profiles. Conclusions: Subjects with IGT and NDD, but not isolated IFG, exhibit a greater arterial stiffness.

原文English
頁(從 - 到)E658-E662
期刊Journal of Clinical Endocrinology and Metabolism
97
發行號4
DOIs
出版狀態Published - 2012 4月

All Science Journal Classification (ASJC) codes

  • 內分泌學、糖尿病和代謝
  • 生物化學
  • 內分泌
  • 臨床生物化學
  • 生物化學(醫學)

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