Increased IL-5 and IL-10 transcription in bronchial cells after Sauropus androgynus ingestion

Chang Wen Chen, Tzuen Ren Hsiue, Kuan Wen Chen, Han Yu Chang, Cheng Ren Chen, Bei Chang Yang

研究成果: Article同行評審

8 引文 斯高帕斯(Scopus)


An outbreak of rapidly progressive obstructive lung disease in Taiwan was noted in some patients regularly ingesting the vegetable Sauropus androgynus because of its perceived weight reducing properties. Bronchoalveolar lavage (BAL) prior to administration of medication was performed in two women who had regularly ingested this vegetable and had developed obstructive ventilatory defects. Both patients showed a significant increase in neutrophils and, to a lesser extent, of eosinophils in the lavage fluid as compared to two unrelated controls. Interleukin (IL)-1β, IL-2, IL-5, IL-10, interferon (IFN)-γ and tumor necrosis factor (TNF)-α in cells recovered from BAL fluid were analyzed by reverse transcription-polymerase chain reaction (RT-PCR). Augmented expression of the IL-10 gene was detected in only two patients who had regularly ingested S. androgynus. Our results suggest that altered cytokine expression and infiltration of eosinophils and neutrophils may be involved in the pathology of obstructive lung disease caused by regular ingestion of S. androgynus.

頁(從 - 到)699-702
期刊Journal of the Formosan Medical Association
出版狀態Published - 1996 九月 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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