Increased risk of hip fractures in patients with dementia: A nationwide population-based study

Hao Kuang Wang, Chao Ming Hung, Sheng Hsiang Lin, Yi Cheng Tai, Kang Lu, Po Chou Liliang, Chi Wei Lin, Yi Che Lee, Pei Hsuan Fang, Li Ching Chang, Ying Chun Li

研究成果: Article同行評審

52 引文 斯高帕斯(Scopus)


Background: Dementia has been associated with an increased risk of hip fracture. However, little research has been conducted on the impact of dementia on wrist or vertebral fracture development. The aim of this study was to investigate whether dementia is a risk factor for different types of fracture in Taiwan. Methods: The study sample was drawn from Taiwan's National Health Insurance Research Database of reimbursement claims, and comprised 1408 patients who visited ambulatory care centers or were hospitalized with a diagnosis of dementia. The comparison group consisted of 7040 randomly selected individuals. Cox proportional hazard regression model was used to examine associations between dementia and the risk of different types of fracture. Results: During a 3-year follow-up period, 264 patients with dementia (18.75%) and 1098 patients without dementia (15.60%) developed fractures. Dementia was independently associated with increased risk of hip fracture [adjusted hazard ratio (HR) 1.92, 95% CI 1.48-2.49]. Patients with dementia and osteoporosis had the highest risk of developing hip fracture (adjusted HR 2.27, 95% CI 1.28-4.01). Dementia did not increase wrist fracture or vertebral fracture risk when compared to the control group, even in patients with osteoporosis. Conclusions: Individuals with dementia are at greater risk of developing hip fracture, particularly if they also have osteoporosis. Early mental screening programs and health education should be initiated to decrease disability and dependence in patients with dementia.

期刊BMC Neurology
出版狀態Published - 2014 九月 12

All Science Journal Classification (ASJC) codes

  • 神經病學(臨床)


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