Increased upper and lower tract Urothelial carcinoma in patients with end-stage renal disease: A nationwide cohort study in Taiwan during 1997-2008

Shuo Meng Wang, Ming Nan Lai, Pau Chung Chen, Yeong Shiau Pu, Ming Kuen Lai, Jing Shiang Hwang, Jung Der Wang

研究成果: Review article

20 引文 (Scopus)

摘要

Background. Urothelial cancer (UC) is the leading cancer of patients with end-stage renal disease (ESRD) in Taiwan. The aims of this study were to explore the time trends of UC incidences and propose possible etiologic factors. Methods. Abstracting from the National Health Insurance Research Database (NHIRD), there were 90,477 newly diagnosed cases of ESRD between 1997 and 2008 covering the patients aged 40-85. Among them, 2,708 had developed UC after diagnosis of ESRD. The CIR40-85 (cumulative incidence rate) of upper tract UC (UTUC) and lower tract UC (LTUC) were calculated for ESRD patients and general population, as well as SIR40-85 (standardized incidence ratio) for comparison. Results. Female ESRD patients were found to have 9-18 times of elevated risks of UC, while those of males were increased up to 4-14 times. The time trends of CIR40-84 and SIR40-84 of UTUC in females appear to decline after calendar year 2000. These trends may be related to AA associated herbal products after 1998. Conclusions. Patients with ESRD are at increased risks for both LTUC and UTUC in Taiwan. We hypothesize that the time trends associate with the consumption of aristolochic acid in Chinese herbal products (female predominant).

原文English
文章編號149750
期刊BioMed research international
2014
DOIs
出版狀態Published - 2014

指紋

Taiwan
Chronic Kidney Failure
Cohort Studies
Carcinoma
Neoplasms
Incidence
Health insurance
National Health Programs
Databases
Research
Population

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

引用此文

Wang, Shuo Meng ; Lai, Ming Nan ; Chen, Pau Chung ; Pu, Yeong Shiau ; Lai, Ming Kuen ; Hwang, Jing Shiang ; Wang, Jung Der. / Increased upper and lower tract Urothelial carcinoma in patients with end-stage renal disease : A nationwide cohort study in Taiwan during 1997-2008. 於: BioMed research international. 2014 ; 卷 2014.
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abstract = "Background. Urothelial cancer (UC) is the leading cancer of patients with end-stage renal disease (ESRD) in Taiwan. The aims of this study were to explore the time trends of UC incidences and propose possible etiologic factors. Methods. Abstracting from the National Health Insurance Research Database (NHIRD), there were 90,477 newly diagnosed cases of ESRD between 1997 and 2008 covering the patients aged 40-85. Among them, 2,708 had developed UC after diagnosis of ESRD. The CIR40-85 (cumulative incidence rate) of upper tract UC (UTUC) and lower tract UC (LTUC) were calculated for ESRD patients and general population, as well as SIR40-85 (standardized incidence ratio) for comparison. Results. Female ESRD patients were found to have 9-18 times of elevated risks of UC, while those of males were increased up to 4-14 times. The time trends of CIR40-84 and SIR40-84 of UTUC in females appear to decline after calendar year 2000. These trends may be related to AA associated herbal products after 1998. Conclusions. Patients with ESRD are at increased risks for both LTUC and UTUC in Taiwan. We hypothesize that the time trends associate with the consumption of aristolochic acid in Chinese herbal products (female predominant).",
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Increased upper and lower tract Urothelial carcinoma in patients with end-stage renal disease : A nationwide cohort study in Taiwan during 1997-2008. / Wang, Shuo Meng; Lai, Ming Nan; Chen, Pau Chung; Pu, Yeong Shiau; Lai, Ming Kuen; Hwang, Jing Shiang; Wang, Jung Der.

於: BioMed research international, 卷 2014, 149750, 2014.

研究成果: Review article

TY - JOUR

T1 - Increased upper and lower tract Urothelial carcinoma in patients with end-stage renal disease

T2 - A nationwide cohort study in Taiwan during 1997-2008

AU - Wang, Shuo Meng

AU - Lai, Ming Nan

AU - Chen, Pau Chung

AU - Pu, Yeong Shiau

AU - Lai, Ming Kuen

AU - Hwang, Jing Shiang

AU - Wang, Jung Der

PY - 2014

Y1 - 2014

N2 - Background. Urothelial cancer (UC) is the leading cancer of patients with end-stage renal disease (ESRD) in Taiwan. The aims of this study were to explore the time trends of UC incidences and propose possible etiologic factors. Methods. Abstracting from the National Health Insurance Research Database (NHIRD), there were 90,477 newly diagnosed cases of ESRD between 1997 and 2008 covering the patients aged 40-85. Among them, 2,708 had developed UC after diagnosis of ESRD. The CIR40-85 (cumulative incidence rate) of upper tract UC (UTUC) and lower tract UC (LTUC) were calculated for ESRD patients and general population, as well as SIR40-85 (standardized incidence ratio) for comparison. Results. Female ESRD patients were found to have 9-18 times of elevated risks of UC, while those of males were increased up to 4-14 times. The time trends of CIR40-84 and SIR40-84 of UTUC in females appear to decline after calendar year 2000. These trends may be related to AA associated herbal products after 1998. Conclusions. Patients with ESRD are at increased risks for both LTUC and UTUC in Taiwan. We hypothesize that the time trends associate with the consumption of aristolochic acid in Chinese herbal products (female predominant).

AB - Background. Urothelial cancer (UC) is the leading cancer of patients with end-stage renal disease (ESRD) in Taiwan. The aims of this study were to explore the time trends of UC incidences and propose possible etiologic factors. Methods. Abstracting from the National Health Insurance Research Database (NHIRD), there were 90,477 newly diagnosed cases of ESRD between 1997 and 2008 covering the patients aged 40-85. Among them, 2,708 had developed UC after diagnosis of ESRD. The CIR40-85 (cumulative incidence rate) of upper tract UC (UTUC) and lower tract UC (LTUC) were calculated for ESRD patients and general population, as well as SIR40-85 (standardized incidence ratio) for comparison. Results. Female ESRD patients were found to have 9-18 times of elevated risks of UC, while those of males were increased up to 4-14 times. The time trends of CIR40-84 and SIR40-84 of UTUC in females appear to decline after calendar year 2000. These trends may be related to AA associated herbal products after 1998. Conclusions. Patients with ESRD are at increased risks for both LTUC and UTUC in Taiwan. We hypothesize that the time trends associate with the consumption of aristolochic acid in Chinese herbal products (female predominant).

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